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Scholar Results 1 - 10 of about 101 related to Bell: Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets. (0.09 sec) 

Rapamycin has a deleterious effect on MIN-6 cells and rat and human islets


E Bell, X Cao, JA Moibi, SR Greene, R Young, … - Diabetes, 2003 - Am Diabetes Assoc
Rapamycin (sirolimus) is a macrolide fungicide with immunosuppressant properties
that is used in human islet transplantation. Little is known about the effects
of rapamycin on MIN-6 cells and islets. Rapamycin had a dose-dependent, ...
Cited by 73 - Related articles - BL Direct - All 4 versions

Elevated portal vein drug levels of sirolimus and tacrolimus in islet transplant recipients: …


NM Desai, JA Goss, S Deng, BA Wolf, E … - Transplantation, 2003 - journals.lww.com
Desai, Niraj M.; Goss, John A.; Deng, Shaoping; Wolf, Bryan A.; Markmann,
Eileen; Palanjian, Maral; Shock, Angela P.; Feliciano, Sue; Brunicardi, F.
Charles; Barker, Clyde F.; Naji, Ali; Markmann, James F.
Cited by 48 - Related articles - BL Direct - All 3 versions

Inhibitory Effects of Immunosuppressive Drugs on Insulin Secretion From Hit-T15 Cells and …


BW Paty, JS Harmon, CL Marsh, RP … - Transplantation, 2002 - journals.lww.com
Copyright © 2002 by Lippincott Williams & Wilkins, Inc. ... INHIBITORY EFFECTS
OF IMMUNOSUPPRESSIVE DRUGS ON INSULIN SECRETION FROM HIT-T15 CELLS AND WISTAR
RAT ISLETS1 ... BW PATY,2,3 JS HARMON,2 CL MARSH,4
Cited by 72 - Related articles - BL Direct - All 4 versions

The portal immunosuppressive storm: relevance to islet transplantation?


AM Shapiro, HL Gallant, EG Hao, JRT Lakey, … - Therapeutic drug monitoring, 2005 - journals.lww.com
Abstract: Outcomes in clinical islet transplantation improved substantially with
the introduction of combined sirolimus and tacrolimus immunosuppression.
However, multiple islet preparations are often required to achieve insulin ...
Cited by 41 - Related articles - All 4 versions

Sirolimus is associated with reduced islet engraftment and impaired β-cell function

- diabetesjournals.org
N Zhang, D Su, S Qu, T Tse, R Bottino, AN … - Diabetes, 2006 - Am Diabetes Assoc
Successful islet transplantation depends on the infusion of sufficiently large
quantities of islets, but only a fraction of transplanted islets can survive and
become engrafted, and yet the underlying mechanism remains unclear. In this ...
Cited by 41 - Related articles - BL Direct - All 7 versions

The Metabolic Impact of Rapamycin (Sirolimus) in Chronic Canine Islet Graft Recipients 1


NM Kneteman, JRT Lakey, T Wagner, D … - Transplantation, 1996 - journals.lww.com
Transplantation. Wolters Kluwer Health Logo. All Issues. ...
Cited by 35 - Related articles - BL Direct - All 3 versions

Hepatocyte growth factor gene therapy for pancreatic islets in diabetes: reducing the minimal …

- endojournals.org
JC Lopez-Talavera, A Garcia-Ocana, I Sipula, … - Endocrinology, 2004 - Endocrine Soc
Islet transplantation for diabetes is limited by the availability of human islet
donors. Hepatocyte growth factor (HGF) is a potent ß-cell mitogen and survival
factor and improves islet transplant outcomes in a murine model. However, ...
Cited by 62 - Related articles - BL Direct - All 5 versions

Adenovirus-mediated XIAP gene transfer reverses the negative effects of immunosuppressive …

- diabetesjournals.org
H Hui, N Khoury, X Zhao, L Balkir, ED'Amico, A … - Diabetes, 2005 - Am Diabetes Assoc
Immunosuppressive drugs are routinely used to provide tolerance after whole
pancreas and islet cell transplantations. While they are essential in inhibiting
graft rejection, little is known about their effect on islet function and ...
Cited by 32 - Related articles - All 5 versions

In vivo effect of FK506 on human pancreatic islets


C RICORDI, Y ZENG, R ALEJANDRO, A … - Transplantation, 1991 - journals.lww.com
September 1991 RICORDI ET AL. 519 pathogenic and sympathizing eyes. Arch
Ophthalmol 1964; 72: 9. 12. Niederkorn JY, Shadduck JA, Streilein JW.
Immunogenetic basis for immunologic privilege in the anterior chamber of ...
Cited by 70 - Related articles - All 3 versions

The impact of the mTOR inhibitor sirolimus on the proliferation and function of pancreatic …


CT Bussiere, JRT Lakey, AMJ Shapiro, GS … - Diabetologia, 2006 - Springer
Abstract Aims/hypothesis The Edmonton Protocol for islet trans- plantation has
provided hope for type 1 diabetic patients. However, this protocol requires
lifelong immunosuppres- sion, specifically sirolimus, a cellular ...
Cited by 28 - Related articles - BL Direct - All 4 versions


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