PJ Klover, TA Zimmers, LG Koniaris, RA … - Diabetes, 2003 - Am Diabetes Assoc Interleukin (IL)-6 is one of several proinflammatory cytokines associated with
the insulin resistance of obesity and type 2 diabetes. There is, however, little
direct evidence in vivo for a causative role of IL-6 in insulin resistance. ... Cited by 162 - Related articles - BL Direct - All 4 versions
PJ Klover, AH Clementi, RA Mooney - Endocrinology, 2005 - Endocrine Soc Obesity and insulin resistance are considered chronic inflammatory states, in
part because circulating IL-6 is elevated. Exogenous IL-6 can induce hepatic
insulin resistance in vitro and in vivo. The importance of endogenous IL-6, ... Cited by 92 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JJ Senn, PJ Klover, IA Nowak, RA Mooney - Diabetes, 2002 - Am Diabetes Assoc Interleukin (IL)-6 is one of several proinflammatory cytokines that have been
associated with insulin resistance and type 2 diabetes. A two- to threefold
elevation of circulating IL-6 has been observed in these conditions. ... Cited by 315 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org HJ Kim, T Higashimori, SY Park, H Choi, J … - Diabetes, 2004 - Am Diabetes Assoc The circulating level of the inflammatory cytokine interleukin (IL)-6 is
elevated in various insulin-resistant states including type 2 diabetes, obesity,
cancer, and HIV-associated lipodystrophy. To determine the role of IL-6 in ... Cited by 164 - Related articles - BL Direct - All 4 versions
JJ Senn, PJ Klover, IA Nowak, TA Zimmers, … - Journal of Biological Chemistry, 2003 - ASBMB Interleukin-6 (IL-6) is one of several pro-inflammatory cytokines implicated in
insulin resistance during infection, cachexia, and obesity. We recently
demonstrated that IL-6 inhibits insulin signaling in hepatocytes (Senn, JJ, ... Cited by 273 - Related articles - BL Direct - All 9 versions
- ►physiology.org GB Di Gregorio, L Hensley, T Lu, G … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Obesity-related insulin resistance may be caused by adipokines such as IL-6,
which is known to be elevated with the insulin resistance syndrome. A previous
study reported that IL-6 knockout mice (IL-6 –/– ) developed maturity ... Cited by 51 - Related articles - All 3 versions
C Lagathu, JP Bastard, M Auclair, M Maachi, … - Biochemical and Biophysical Research …, 2003 - Elsevier IL-6 has emerged as an important cytokine upregulated in states of insulin
resistance such as type 2 diabetes. We evaluated the chronic effect of IL-6 on
insulin signaling in 3T3-F442A and 3T3-L1 adipocytes. First, cells ... Cited by 141 - Related articles - All 5 versions
- ►jbc.org V Rotter, I Nagaev, U Smith - Journal of Biological Chemistry, 2003 - ASBMB Several studies have shown a relationship between interleukin (IL) 6 levels and
insulin resistance. We here show that human subcutaneous adipose cells, like
3T3-L1 cells, are target cells for IL-6. To examine putative mechanisms and ... Cited by 276 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org MA Febbraio, N Hiscock, M Sacchetti, CP … - Diabetes, 2004 - Am Diabetes Assoc The mechanisms that mediate the tightly controlled production and clearance of
glucose during muscular work are unclear, and it has been suggested that an
unidentified “work factor” exists that influences the ... Cited by 83 - Related articles - BL Direct - All 5 versions
- ►physiology.org EW Petersen, AL Carey, M Sacchetti, GR … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc To determine whether IL-6 increases lipolysis and fat oxidation in patients with
type 2 diabetes and/or whether it exerts this effect independently of changes to
the hormonal milieu, patients with type 2 diabetes (D) and healthy control ... Cited by 62 - Related articles - All 6 versions
