I Goren, H Kämpfer, M Podda, J Pfeilschifter, S Frank - Diabetes, 2003 - Am Diabetes Assoc In this study, we investigated the role of leptin for the inflammatory response in diabetes-impaired
skin repair. We demonstrated, that systemic treatment of diabetic ob/ob mice with leptin blunted
polymorphonuclear neutrophil (PMN), but not macrophage influx into the wound site. ... Cited by 44 - Related articles - BL Direct - All 4 versions
I Goren, E Müller, D Schiefelbein, U … - J Invest …, 2007 - urschristen.homepage.t-online.de To date, diabetes-associated skin ulcerations represent a therapeutic problem of clinical
importance. The insulin-resistant type II diabetic phenotype is functionally connected to obesity
in rodent models of metabolic syndrome through the release of inflammatory mediators ... Cited by 18 - Related articles - View as HTML - BL Direct - All 7 versions
K Rosner, C Ross, T Karlsmark, AA Petersen, F Gottrup … - Apmis, 1995 - interscience.wiley.com Current understanding of the immunological mechanisms involved in the pathogenesis of venous
leg ulcers is insufficient. In this study the cellular composition of skin biopsies taken from the
center, the edge, and 2 cm distant from the edge of venous leg ulcers was characterized ... Cited by 35 - Related articles - BL Direct - All 3 versions
C Wetzler, H Kämpfer, B Stallmeyer, J Pfeilschifter … - Journal of Investigative …, 2000 - nature.com Chemokines are seen as the stimuli that largely control leukocyte migration. To assess whether
the severely impaired process of cutaneous repair observed in genetically diabetic db/db mice
is associated with a dysregulated infiltration of immune cells, we determined the ... Cited by 131 - Related articles - BL Direct - All 3 versions
- ►amjpathol.org I Goren, E Muller, J Pfeilschifter, S Frank - American Journal of Pathology, 2006 - ASIP The functional connection between diabetes and foot ulceration was first recognized by the surgeon
TD Pryce in 1887. 1 For the first time, Pryce claimed in an article published in Lancet that "diabetes
itself may play an active part in the causation of perforating ulcers." 1 Diabetic foot ulcers ... Cited by 20 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org S Ikejima, S Sasaki, H Sashinami, F Mori, Y Ogawa, T … - Diabetes, 2005 - Am Diabetes Assoc Leptin is an adipocyte-derived hormone that regulates a number of physiological functions, including
energy homeostasis and immune function. In immune responses, leptin plays a role in the induction
of inflammation. We investigated a role of leptin in Listeria monocytogenes infection using ... Cited by 27 - Related articles - All 6 versions
- ►nih.gov [PDF] S Frank, B Stallmeyer, H Kämpfer, N Kolb, … - Journal of Clinical …, 2000 - Am Soc Clin Investig Wound-healing disorders are a therapeutic problem of extensive clinical importance.
Leptin-deficient ob/ob mice are characterized by a severely delayed wound healing that has
been explained by the mild diabetic phenotype of these animals. Here we demonstrate ... Cited by 139 - Related articles - BL Direct - All 9 versions
E Faglia, F Favales, A Morabito - Diabetes Care, 2001 - cat.inist.fr OBJECTIVE- To evaluate 1) the new ulceration, the new major amputation, and the survival rates
of 115 diabetic subjects hospitalized for foot ulceration from 1990 to 1993, with an average
follow-up of 6. 5 years, and 2) the demographic and clinical characteristics associated ... Cited by 58 - Related articles - BL Direct - All 3 versions
- ►nutritionsociety.org.uk [PDF] CA Mattacks, D Sadler, CM Pond - British Journal of Nutrition, 2007 - Cambridge Univ Press The effects of dietary lipids on the abundance of dendritic cells in adipose tissue in anatomically
defined relationships to chronically inflamed lymph nodes were investigated in mature male
rats fed plain chow or chow plus 20 % sunflower-seed or fish oil. The popliteal lymph ... Cited by 16 - Related articles - BL Direct - All 8 versions
- ►jimmunol.org L Macia, M Delacre, G Abboud, TS Ouk, A … - The Journal of …, 2006 - Am Assoc Immnol There is a finely tuned interplay between immune and neuroendocrine systems. Metabolic disturbances
like obesity will have serious consequences on immunity both at the cellular and at the cytokine
expression levels. Our in vivo results confirm the immune deficiency of ob/ob mice, leptin ... Cited by 17 - Related articles - BL Direct - All 5 versions
