D Kawamori, Y Kajimoto, H Kaneto, Y … - Diabetes, 2003 - Am Diabetes Assoc Oxidative stress is induced in pancreatic β-cells under diabetic conditions and
causes β-cell dysfunction. Antioxidant treatment of diabetic animals leads to
recovery of insulin biosynthesis and increases the expression of its ... Cited by 68 - Related articles - BL Direct - All 4 versions
H Kaneto, G Xu, N Fujii, S Kim, S Bonner- … - Journal of Biological Chemistry, 2002 - ASBMB Oxidative stress, which is found in pancreatic β-cells in the diabetic state,
suppresses insulin gene transcription and secretion, but the signaling pathways
involved in the β-cell dysfunction induced by oxidative stress remain ... Cited by 133 - Related articles - BL Direct - All 4 versions
[CITATION] Activation of the hexosamine pathway leads to deterioration of pancreatic β-cell function by …
S Gorogawa, Y Kajimoto, Y Umayahara, H … - Diabetes research and clinical practice, 2002 - Elsevier Oxidative stress is induced under diabetic conditions and causes various forms
of tissue damage in patients with diabetes. Recently, pancreatic β-cells have
emerged as a putative target of oxidative stress-induced tissue damage and ... Cited by 50 - Related articles - All 10 versions
- ►jbc.org D Kawamori, H Kaneto, Y Nakatani, T … - Journal of Biological Chemistry, 2006 - ASBMB It has been shown that oxidative stress and activation of the c-Jun N-terminal
kinase (JNK) pathway induce the nucleocytoplasmic translocation of the
pancreatic transcription factor PDX-1, which leads to pancreatic -cell ... Cited by 43 - Related articles - BL Direct - All 8 versions
Y Kajimoto, T Matsuoka, H Kaneto, H Watada, … - Diabetologia, 1999 - Springer Although glucose is the major physiologic stimulator of insulin secretion and
biosynthesis in vivo, pro- longed exposure of pancreatic beta cells to a high
glu- ... Induction of glycation suppresses glucokinase gene expression Cited by 39 - Related articles - All 5 versions
[CITATION] The human glucokinase gene β-cell-type promoter: an essential role of insulin promoter factor …
Y Tanaka, POT Tran, J Harmon, RP … - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences Antioxidant drugs have been reported to protect pancreatic islets from the
adverse effects of chronic exposure to supraphysiological glucose
concentrations. However, glucose has not been shown to increase ... Cited by 115 - Related articles - BL Direct - All 10 versions
- ►nih.gov [PDF] T Matsuoka, Y Kajimoto, H Watada, H Kaneto, … - Journal of Clinical Investigation, 1997 - pubmedcentral.nih.gov Prolonged poor glycemic control in non–insulin-dependent diabetes mellitus
patients often leads to a decline in insulin secretion from pancreatic cells,
accompanied by a de- crease in the insulin content of the cells. As a step ... Cited by 145 - Related articles - BL Direct - All 13 versions
H Noguchi, H Kaneto, GC Weir, S Bonner- … - Diabetes, 2003 - Am Diabetes Assoc The pancreatic and duodenal homeobox factor-1 (PDX-1), also known as IDX-1/STF-1
/IPF1, a homeodomain-containing transcription factor, plays a central role in
regulating pancreatic development and insulin gene transcription. ... Cited by 109 - Related articles - BL Direct - All 6 versions
