- ►harvard.edu [PDF] SP Berzins, ES Venanzi, C Benoist, D Mathis - Diabetes, 2003 - Am Diabetes Assoc Given the importance of the NOD mouse as a model of type 1 diabetes, there is a
surprising lack of published information on the overall composition of the
thymic and peripheral T-cell compartments. In this study, we revisited some ... Cited by 45 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org S Gregori, N Giarratana, S Smiroldo, L Adorini - The Journal of Immunology, 2003 - Am Assoc Immnol In the nonobese diabetic (NOD) mouse, pathogenic and suppressor CD4 + T cells
can be distinguished by the constitutive expression of CD25. In this study, we
demonstrate that the progression of autoimmune diabetes in NOD mice ... Cited by 125 - Related articles - BL Direct - All 4 versions
- ►pnas.org AM D'Alise, V Auyeung, M Feuerer, J Nishio, J … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences FoxP3 + regulatory T cells (Tregs) protect against autoimmunity, type 1 diabetes
(T1D) in particular, prompting the hypothesis that a deficiency in Tregs is a
critical determinant of diabetes susceptibility in NOD mice. However, tests ... Cited by 8 - Related articles - All 7 versions
M von Herrath, D Homann - Trends in immunology, 2003 - Elsevier The concept of therapeutic immune regulation aiming to treat autoimmune diseases
has been validated in multiple animal models, yet, the development of strategies
for treatment of human autoimmune diseases remains problematic. Main ... Cited by 13 - Related articles - All 4 versions
M Dardenne, F Lepault, A Bendelac, JF Bach - Eur J Immunol, 1989 - interscience.wiley.com The effect of thymectomy performed at weaning (3 weeks) and at 6-7 weeks of age
on the incidence of diabetes was examined in the non-Obese diabetic (NOD) mouse,
a spontaneous model of immunologically mediated insulin-dependent diabetes ... Cited by 80 - Related articles - All 3 versions
- ►j-talk.com R Spolski, M Kashyap, C Robinson, Z Yu, WJ … - Proceedings of the National Academy of Sciences, 2008 - National Acad Sciences IL-21 is a pleiotropic type I cytokine that shares the common cytokine receptor
γ chain and plays important roles for normal Ig production, terminal B cell
differentiation to plasma cells, and Th17 differentiation. IL-21 is ... Cited by 18 - Related articles - All 8 versions
PR Hutchings, A Cooke - Journal of autoimmunity, 1990 - ncbi.nlm.nih.gov The NOD mouse is characterized by the development of spontaneous autoimmune
diabetes which begins with a peri-islet lymphocyte infiltration of the pancreas
around 6 weeks of age and progresses to overt diabetes in 50-60% of females ... Cited by 49 - Related articles
R Mukherjee, P Chaturvedi, HY Qin, B Singh - Journal of Autoimmunity, 2003 - Elsevier NOD mice have a relative deficiency of CD4 + CD25 + regulatory T cells that
could result in an inability to maintain peripheral tolerance. The aim of this
study was to induce the generation of CD4 + CD25 + regulatory T cells in ... Cited by 50 - Related articles - All 4 versions
H Kishimoto, J Sprent - Nature Immunology, 2001 - nature.com The predisposition of nonobese diabetic (NOD) mice to develop autoimmune disease
is usually attributed to defects in peripheral tolerance mechanisms. Here,
evidence is presented that NOD mice display a defect in central tolerance ( ... Cited by 148 - Related articles - BL Direct - All 2 versions
B Stockinger, T Barthlott, G Kassiotis - Nature immunology, 2001 - ncbi.nlm.nih.gov 1: Nat Immunol. 2001 Sep;2(9):757-8. T cell regulation: a special job or everyone's
responsibility? Stockinger B, Barthlott T, Kassiotis G. ... Cited by 39 - Related articles - BL Direct - All 4 versions
