- ►diabetesjournals.org G Rajagopalan, YC Kudva, RA Flavell, CS David - Diabetes, 2003 - Am Diabetes Assoc The major predisposing genetic component in type 1 diabetes maps to the major histocompatibility
complex locus in both mice and humans. To verify the HLA class II association with disease
pathogenesis, we adopted the transgenic approach. Expression of HLA-DQ8, the ... Cited by 10 - Related articles - BL Direct - All 4 versions
YC Kudva, G Rajagopalan, R Raju, RS Abraham, M … - Human Immunology, 2002 - Elsevier To evaluate the contributions of DR3 and DQ8 to the etiopathogenesis of type 1 diabetes in a
diabetes-predisposing milieu, we developed human leukocyte antigen (HLA) transgenic mice
on the nonobese diabetic (NOD) background in the absence of the endogenous class II ... Cited by 14 - Related articles - All 4 versions
L Wen, FS Wong, R Sherwin, C Mora - Journal of immunology ( …, 2002 - ncbi.nlm.nih.gov The strong association of type 1 diabetes with specific MHC class II genes, such as IA(g7) in
nonobese diabetic mice and HLA-DQ8 in humans, suggests that MHC class II molecules play
an important role in the development of the disease. To test whether human DQ8 ... Cited by 15 - Related articles - BL Direct
- ►oxfordjournals.org G Rajagopalan, YC Kudva, L Chen, L Wen, … - International …, 2003 - Jpn Soc Immunol The major predisposing genetic component in type 1 diabetes (T1D) maps to the MHC locus
in both mice and humans. To better understand the HLA class II association with disease
pathogenesis, we bred mice expressing HLA-DQ8 and -DR3, either alone or in ... Cited by 9 - Related articles - All 4 versions
GRYCK Richard, A Flavell, CS David - 糖尿病学杂志, 2003 - journal.shouxi.net The major predisposing genetic component in type 1 diabetes maps to the major histocompatibility
complex locus in both mice and humans. To verify the HLA class II association with disease
pathogenesis, we adopted the transgenic approach. Expression of HLA-DQ8, the ... Related articles - Cached
- ►jimmunol.org E Havari, AM Lennon-Dumenil, L Klein, D … - The Journal of …, 2004 - Am Assoc Immnol Although HLA-DQ8 has been implicated as a key determinant of genetic susceptibility to human
type 1 diabetes, spontaneous diabetes has been observed in HLA-DQ8 transgenic mice that
lack expression of murine MHC class II molecules (mII –/– ) only when the potent ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►nih.gov L Wen, NY Chen, J Tang, R Sherwin, FS … - Journal of Clinical …, 2001 - Am Soc Clin Investig MHC class II molecules are critical determinants of genetic susceptibility to human type 1
diabetes. In patients, the most common haplotype contains the DRA1*0101-DRB1*0401
(DR4) and DQA1*0301-DQB1*0302 (DQ8) loci. To assess directly the relative roles of ... Cited by 38 - Related articles - BL Direct - All 7 versions
R Raju, SR Munn, C Majoribanks, CS David - Transplantation proceedings, 1998 - Elsevier Type I diabetes is an autoimmune disease with a strong genetic predisposition as seen by the
presence of specific HLA haplotypes like HLA DR3, DR4, DQ8, and/or DQ2.[1] However, the
role of any particular HLA allele in the development of the disease is still unclear due to ... Cited by 10 - Related articles - BL Direct - All 8 versions
- ►jimmunol.org RS Abraham, L Wen, EV Marietta, CS … - The Journal of …, 2001 - Am Assoc Immnol The genetic factors that contribute to the etiology of type 1 diabetes are still largely
uncharacterized. However, the genes of the MHC (HLA in humans) have been consistently associated
with susceptibility to disease. We have used several transgenic mice generated in our ... Cited by 21 - Related articles - BL Direct - All 3 versions
G Rajagopalan, AK Mangalam, MM Sen, YC … - …, 2007 - informahealthcare.com The strong MHC class II association in human as well as murine Type 1 diabetes (T1D) suggests
a central role for CD4 + T cells in the disease pathogenesis. Nonetheless, CD8 + T cells also
play a role in the pathogenic process. We describe how CD4 + or CD8 + T cells can ... Cited by 2 - Related articles - BL Direct - All 5 versions
