B Kutlu, MI Darville, AK Cardozo, DL Eizirik - Diabetes, 2003 - Am Diabetes Assoc Pancreatic β-cells are selectively destroyed during the course of type 1 diabetes. In the early
stages of the disease, inflammatory infiltrates of mononuclear cells, containing predominantly
monocytes and T-cells, are present ... Cited by 56 - Related articles - BL Direct - All 5 versions
MC Chen, P Proost, C Gysemans, C Mathieu, DL Eizirik - Diabetologia, 2001 - Springer Type I (insulin-dependent) diabetes mellitus is an au- toimmune disease characterized by the
selective de- struction of insulin-producing beta cells in the pan- creatic islets of Langerhans
[1]. This process is usually ... Cited by 99 - Related articles - BL Direct - All 5 versions
AK Cardozo, H Heimberg, Y Heremans, R Leeman, … - Journal of Biological …, 2001 - ASBMB Type 1 diabetes mellitus results from an autoimmune destruction of pancreatic -cells. Cytokines,
such as interleukin-1 and interferon- , are putative mediators of immune-induced -cell death and,
under in vitro conditions, cause ... Cited by 159 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org MI Darville, DL Eizirik - Diabetes, 2001 - Am Diabetes Assoc Fas-mediated cell death may play a role in the autoimmune destruction of pancreatic β-cells in type
1 diabetes. β-Cells do not express Fas under physiological conditions, but Fas mRNA and protein are
induced in cytokine-exposed mouse ... Cited by 60 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MI Darville, YS Ho, DL Eizirik - Endocrinology, 2000 - Endocrine Soc Reactive oxygen species play an important role in the cytotoxic effect of inflammatory cytokines on
pancreatic ß-cells in type 1 diabetes mellitus. The antioxidant enzyme manganese superoxide
dismutase (MnSOD) is part of the ... Cited by 63 - Related articles - BL Direct - All 2 versions
- ►endojournals.org D Liu, AK Cardozo, MI Darville, DL Eizirik - Endocrinology, 2002 - Endocrine Soc Viral infections may trigger the autoimmune assault leading to type 1 diabetes mellitus.
Double-stranded RNA (dsRNA) is produced by many viruses during their replicative cycle. The dsRNA,
tested as synthetic poly(IC) (PIC), ... Cited by 51 - Related articles - BL Direct - All 4 versions
MI Darville, DL Eizirik - Diabetologia, 1998 - Springer Type I (insulin-dependent) diabetes mellitus results from a selective destruction of the pancreatic
insu- lin-producing beta cells. Cytokines, especially inter- leukin-1b (IL-1b), could play an
important role in im- mune-induced ... Cited by 113 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org H Heimberg, Y Heremans, C Jobin, R Leemans, AK … - Diabetes, 2001 - Am Diabetes Assoc Cytokine-induced β-cell death is an important event in the pathogenesis of type 1 diabetes. The
transcription factor nuclear factor-κB (NF-κB) is activated by interleukin-1β (IL-1β), and its
activity promotes the expression of ... Cited by 129 - Related articles - BL Direct - All 4 versions
IN ADDITION - Endocrinology, 2002 - Endocrine Soc Page 1. Double-Stranded RNA Cooperates with Interferon- and IL-1 to Induce Both Chemokine
Expression and Nuclear Factor- B-Dependent Apoptosis in Pancreatic -Cells: Potential Mechanisms
for Viral-Induced Insulitis and -Cell Death in Type 1 Diabetes Mellitus ... Cited by 8 - Related articles
AK Cardozo, P Proost, C Gysemans, MC Chen, C … - Diabetologia, 2003 - Springer Aims/hypothesis. Cytokines and chemokines are im- portant mediators of immune responses due to their
ability to recruit and activate leukocytes. Using micro- array analysis we observed that rat beta
cells exposed to IL-1β and IFN-γ ... Cited by 86 - Related articles - BL Direct - All 5 versions
