- ►diabetesjournals.org RL Hull, S Andrikopoulos, CB Verchere, J … - Diabetes, 2003 - Am Diabetes Assoc Transgenic mice expressing the amyloidogenic human islet amyloid polypeptide
(hIAPP) in their islet β-cells are a model of islet amyloid formation as it
occurs in type 2 diabetes. Our hIAPP transgenic mice developed islet ... Cited by 37 - Related articles - BL Direct - All 7 versions
F Wang, RL Hull, J Vidal, M Cnop, SE Kahn - Diabetes, 2001 - Am Diabetes Assoc Islet amyloid occurs in >90% of type 2 diabetic patients and may play a role in
the pathogenesis of this disease. To determine whether islet amyloid occurs
diffusely throughout the pancreas, whether it affects islets equally, and ... Cited by 40 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org [PDF] S Andrikopoulos, CB Verchere, Y Terauchi, … - Diabetes, 2000 - Am Diabetes Assoc Type 2 diabetes is characterized by impaired -cell function, hyperglycemia, and
islet amyloid deposition. The primary constituent of islet amyloid is the
37–amino acid -cell product called islet amyloid polypeptide (IAPP) or ... Cited by 23 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] WC Soeller, J Janson, SE Hart, JC Parker, MD … - Diabetes, 1998 - Am Diabetes Assoc We have previously shown that hemizygous transgenic mice expressing human islet
amyloid polypeptide (hIAPP) in pancreatic -cells have no diabetic pheno- type,
whereas in the homozygous state, they developed severe, early-onset ... Cited by 94 - Related articles - BL Direct - All 6 versions
DA D'Alessio, CB Verchere, SE Kahn, V … - Diabetes, 1994 - Am Diabetes Assoc Islet amyloid polypeptide (IAPP) is a secretory product of the pancreatic
beta-cell, which is the primary constituent of the islet amyloid that develops
in type II diabetes. To study the role the inherent amyloidogenicity of ... Cited by 52 - Related articles - BL Direct - All 5 versions
SE Kahn, S Andrikopoulos, CB Verchere, F … - Diabetologia, 2000 - Springer Amyloid is present in over 85% of human subjects with Type II
(non-insulin-dependent) diabetes melli- tus [1] with islet amyloid polypeptide
(IAPP or amy- lin) being its unique component [2, 3]. The amyloido- genic ... Cited by 13 - Related articles - BL Direct - All 4 versions
… Höppener, C Oosterwijk, MG Nieuwenhuis, G … - Diabetologia, 1999 - Springer Type II (non-insulin-dependent) diabetes mellitus is a common, age-related,
multifactorial disease [1, 2]. Although still debated, it seems that the primary
de- fect in most subjects developing Type II diabetes in- volves resistance ... Cited by 90 - Related articles - BL Direct - All 4 versions
P Westermark - Upsala journal of medical sciences, 1972 - ncbi.nlm.nih.gov 1: Ups J Med Sci. 1972;77(2):91-4. Quantitative studies on amyloid in the
islets of Langerhans. Westermark P. Mesh Terms: Amyloid ... Cited by 57 - Related articles
J Vidal, C Bruce Verchere, S Andrikopoulos, F … - Diabetologia, 2003 - Springer Aims/hypothesis. Islet amyloid deposits are present in over 85% of Type 2
diabetic patients and have been suggested to be pathogenic. The mechanism that
con- verts islet amyloid polypeptide (IAPP), the unique component of these ... Cited by 14 - Related articles - BL Direct - All 5 versions
DLA MacArthur, EJP De Koning, JS Verbeek, … - Diabetologia, 1999 - Springer Amyloid deposits are found in the islets of Langer- hans of up to 96% of
patients with Type II (non-insu- lin-dependent) diabetes mellitus [1, 2] but the
rela- ... Amyloid fibril formation is progressive and correlates with ... Cited by 17 - Related articles - BL Direct - All 4 versions
