LL Kjems, JJ Holst, A Vølund, S Madsbad - Diabetes, 2003 - Am Diabetes Assoc The intestinally derived hormone glucagon-like peptide 1 (GLP-1) (7-36 amide) has potent effects on
glucose-mediated insulin secretion, insulin gene expression, and β-cell growth and differentiation.
It is, therefore, considered a ... Cited by 139 - Related articles - BL Direct - All 5 versions
T Vilsbøll, T Krarup, S Madsbad, J Holst - Diabetologia, 2002 - Springer Aims/hypothesis. Glucagon-like-peptide-1 (GLP-1) is strongly insulinotropic in patients with Type II
(non- insulin-dependent) diabetes mellitus, whereas glu- cose-dependent insulinotropic polypeptide
(GIP) is less effective. Our ... Cited by 135 - Related articles - BL Direct - All 4 versions
- ►endojournals.org MB Toft-Nielsen, MB Damholt, S Madsbad, LM … - Journal of Clinical …, 2001 - Endocrine Soc To elucidate the causes of the diminished incretin effect in type 2 diabetes mellitus we
investigated the secretion of the incretin hormones, glucagon-like peptide-1 and glucose- dependent
insulinotropic polypeptide and ... Cited by 270 - Related articles - BL Direct - All 6 versions
- ►endojournals.org T Vilsboll, H Agerso, T Krarup, JJ Holst - Journal of Clinical Endocrinology …, 2003 - Endocrine Soc We have previously shown that type 2 diabetic patients have decreased plasma concentrations of
glucagon-like peptide 1 (GLP-1) compared with healthy subjects after ingestion of a standard mixed
meal. This decrease could be caused ... Cited by 125 - Related articles - BL Direct - All 6 versions
- ►endojournals.org T Vilsboll, FK Knop, T Krarup, A Johansen, S … - Journal of Clinical …, 2003 - Endocrine Soc The effect of the insulinotropic incretin hormone, glucagon-like peptide-1 (GLP-1), is preserved in
typical middle-aged, obese, insulin-resistant type 2 diabetic patients, whereas a defective
amplification of the so-called late- ... Cited by 78 - Related articles - BL Direct - All 4 versions
T Vilsbøll, T Krarup, CF Deacon, S Madsbad, JJ Holst - Diabetes, 2001 - Am Diabetes Assoc Incretin hormones importantly enhance postprandial insulin secretion but are rapidly degraded to
inactive metabolites by ubiquitous dipeptidyl peptidase IV. The concentrations of the intact
biologically active hormones remain ... Cited by 300 - Related articles - BL Direct - All 4 versions
MA NAUCK, E HOMBERGER, EG SIEGEL, RC … - Journal of Clinical …, 1986 - Endocrine Soc Both insulin and C-peptide concentrations as well as calculated integrated insulin secretion rates
increased with increasing oral glucose loads. Due to the similarity in the glucose profiles after
all oral loads, almost identical ... Cited by 215 - Related articles - All 3 versions
- ►endojournals.org CF Deacon, MA Nauck, J Meier, K Hucking, JJ … - Journal of Clinical …, 2000 - Endocrine Soc Gastric inhibitory polypeptide (GIP) is susceptible to degradation, but only recently has dipeptidyl
peptidase IV been identified as the enzyme responsible. Most RIAs recognize both intact GIP-(1–42)
and the noninsulinotropic ... Cited by 174 - Related articles - BL Direct - All 4 versions
M Nauck, F Stöckmann, R Ebert, W Creutzfeldt - Diabetologia, 1986 - Springer Summary. Integrated incremental immunoreactive insulin and connecting peptide responses to an oral
glucose load of 50 g and an "isoglycaemic" intravenous glucose infusion, respec- tively, were
measured in 14 Type 2 (non-insulin- ... Cited by 364 - Related articles - All 3 versions
- ►nih.gov [PDF] MA Nauck, MM Heimesaat, C Orskov, JJ … - Journal of Clinical …, 1993 - pubmedcentral.nih.gov In type-2 diabetes, the overall incretin effect is reduced. The present investigation was designed
to compare insulinotropic actions ofexogenous incretin hormones (gastric inhibitory pep- tide IGIPI
and glucagon-like peptide 1 [GLP-1j ... Cited by 505 - Related articles - BL Direct - All 8 versions
