S Bertera, ML Crawford, AM Alexander, GD … - Diabetes, 2003 - Am Diabetes Assoc Islet transplantation is a promising cure for diabetes. However, inflammation,
allorejection, and recurrent autoimmune damage all may contribute to early graft
loss. Pancreatic islets express lower levels of antioxidant genes than most ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, S Bertera, M … - Diabetes, 2002 - Am Diabetes Assoc The most commonly used technical approach to isolate human pancreatic islets
intended for allotransplants generates a product that is hampered by mechanical
and chemical insults, which dramatically reduce the mass of viable and ... Cited by 79 - Related articles - BL Direct - All 5 versions
JD Piganelli, SC Flores, C Cruz, J Koepp, I … - Diabetes, 2002 - Am Diabetes Assoc We present here the first report of a metalloporphyrin-based antioxidant that
can prevent or delay the onset of autoimmune diabetes. Type 1 diabetes is an
autoimmune process whereby T-cells recognize pancreatic β-cell antigens ... Cited by 84 - Related articles - BL Direct - All 4 versions
S Lortz, M Tiedge, T Nachtwey, AE Karlsen, J … - DIABETES-NEW YORK-, 2000 - Am Diabetes Assoc Nitric oxide (NO) and reactive oxygen species (ROS) are crucial elements in
cytokine-mediated -cell destruc- tion. In insulin-producing RINm5F cells,
overexpression of cytoprotective enzymes provides significant protection ... Cited by 126 - Related articles - BL Direct - All 4 versions
AN Balamurugan, Y Chang, JJ Fung, M Trucco … - American Journal of Transplantation, 2003 - interscience.wiley.com Worldwide growing interest in reproducing the result of the Edmonton protocol in
islet transplantation trials poses the problem of paucity of donors to supply
sufficient amount of islets for clinical use. Improved outcomes include ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in
the islets of Langerhans involving activation of apoptosis and necrosis and the
production of proinflammatory molecules that negatively influence islet ... Cited by 72 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] M Tiedge, S Lortz, R Munday, S Lenzen - Diabetes, 1998 - Am Diabetes Assoc To determine the importance of different antioxidative enzymes for the defense
status of insulin-producing cells, the effects of stable overexpression of
glutathione peroxidase (Gpx), catalase (Cat), or Cu/Zn superoxide dismutase ... Cited by 96 - Related articles - BL Direct - All 5 versions
C Moriscot, F Pattou, J Kerr-Conte, MJ … - Diabetologia, 2000 - Springer It has been established from numerous studies that oxygen and nitrogen free
radicals can contribute to the islet beta-cell destruction in Type I
(insulin-de- pendent) diabetes mellitus models [1±2]. The delete- rious ... Cited by 39 - Related articles - BL Direct - All 2 versions
- ►jbc.org A Garcia-Ocana, KK Takane, VT Reddy, JC … - Journal of Biological Chemistry, 2003 - ASBMB Hepatocyte growth factor (HGF) increases beta cell proliferation and function in
rat insulin promoter (RIP)-targeted transgenic mice. RIP-HGF mouse islets also
function superiorly to normal islets in a transplant setting. Here, we ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org H Chen, X Li, PN Epstein - Diabetes, 2005 - Am Diabetes Assoc Reactive oxygen species (ROS) and nitric oxide (NO) are proposed mediators of
cytokine-induced β-cell destruction in type 1 diabetes. We produced transgenic
mice with increased β-cell expression of manganese superoxide dismutase ... Cited by 34 - Related articles - All 6 versions
