- ►diabetesjournals.org JM Moates, S Nanda, MA Cissell, MJ Tsai, R … - Diabetes, 2003 - Am Diabetes Assoc Glucokinase (GK) gene transcription initiates in the islet (ß-cell), gut, and
brain from promoter sequences residing 35 kbp upstream from those used in liver.
Expression of ßGK is controlled in ß-cells by cell-enriched (ie ... Cited by 31 - Related articles - BL Direct - All 5 versions
JM Moates, KD Shelton, MA Magnuson - Molecular Endocrinology, 1996 - Endocrine Soc The upstream glucokinase (GK) promoter is ex- pressed specifically in several
different neural/ neuroendocrine (NE) cell types, including the pancreatic
p-cell and pituitary corticotrope. Previ- ously, a mutational and ... Cited by 14 - Related articles - BL Direct - All 3 versions
E Dumonteil, B Laser, I Constant, J Philippe - Journal of Biological Chemistry, 1998 - ASBMB The insulin and glucagon genes are expressed in the beta and alpha cells of the
islets of Langerhans, respectively. The factors controlling their cell- and
islet-specific expression are poorly known. Insulin-enhancer factor-1 ... Cited by 52 - Related articles - BL Direct - All 4 versions
MA Cissell, L Zhao, L Sussel, E Henderson, R … - Journal of Biological Chemistry, 2003 - ASBMB Consensus-binding sites for many transcription factors are relatively
non-selective and found at high frequency within the genome. This raises the
possibility that factors that are capable of binding to a cis-acting ... Cited by 50 - Related articles - BL Direct - All 4 versions
IB Leibiger, R Walther, U Pett, B Leibiger - FEBS letters, 1994 - cat.inist.fr Positive and negative regulatory elements are involved in transcriptional control
of the rat glucokinase gene in the insulin producing cell line HIT M 2. 2. 2. ... Cited by 13 - Related articles - All 2 versions
- ►nih.gov [PDF] D Bretherton-Watt, N Gore, DS Boam - Biochemical Journal, 1996 - pubmedcentral.nih.gov The islet amyloid polypeptide (IAPP) gene is expressed primarily in the islet
β-cell and the peptide is co-secreted with insulin. To investigate mechanisms
important in its regulation, we have used the electrophoretic ... Cited by 39 - Related articles - BL Direct - All 6 versions
- ►endojournals.org JW Kim, V Seghers, JH Cho, Y Kang, S Kim, Y … - Molecular Endocrinology, 2002 - Endocrine Soc The sulfonylurea receptor 1 (SUR1) plays a key role in regulation of insulin
secretion in pancreatic ß-cells. In this study we investigated the mechanism
for tissue-specific expression of the SUR1 gene. A -138/-20 fragment ... Cited by 19 - Related articles - BL Direct - All 5 versions
TL Jetton, JM Moates, J Lindner, CVE … - Proceedings of the National Academy of Sciences of …, 1998 - National Acad Sciences Transgenic mice containing an upstream glucokinase (βGK) promoter– simian
virus 40 T antigen (Tag) fusion gene develop neuroendocrine tumors primarily in
the pancreas, gut, and pituitary. Pancreatic tumors from a line with ... Cited by 7 - Related articles - BL Direct - All 10 versions
- ►nih.gov [PDF] U Roth, K Jungermann, T Kietzmann - Biochemical Journal, 2002 - pubmedcentral.nih.gov Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a
higher expression in the perivenous zone. In primary rat hepatocytes, the GK
gene expression was activated by HNF (hepatic nuclear factor)-4α via the ... Cited by 21 - Related articles - BL Direct - All 7 versions
B Leibiger, R Walther, IB Leibiger - Biological chemistry Hoppe-Seyler, 1994 - ncbi.nlm.nih.gov Sequence analysis of the 5'flanking region of the beta-cell specific
transcription unit of the rat glucokinase gene (r beta GK) revealed the presence
of sequence motifs very similar to the IEB-(Far)-box and a CT-motif which ... Cited by 12 - Related articles - BL Direct - All 2 versions
