T Izumi, H Yokota-Hashimoto, S Zhao, J Wang … - Diabetes, 2003 - Am Diabetes Assoc Autosomal dominant diabetes in the Akita mouse is caused by mutation of the
insulin 2 gene, whose product replaces a cysteine residue that is engaged in the
formation of an intramolecular disulfide bond. These heterozygous mice ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►nih.gov D Ron - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Mutations that impair polypeptide folding commonly result in an unstable and
hypofunctional gene product. Their phenotype reflects this loss of function, and
the resulting genetic disorder is usually transmitted as a recessive trait. ... Cited by 61 - Related articles - BL Direct - All 14 versions
M Yoshioka, T Kayo, T Ikeda, A Koizumi - Diabetes, 1997 - Am Diabetes Assoc In this article, we report on a nonobese C57BL/6 (B6) mouse model of NIDDM named
Akita mouse, characterized by early age onset and autosomal dominant mode of
inheritance. At 7 weeks of age, the mean morning blood glucose levels ... Cited by 99 - Related articles - BL Direct - All 3 versions
- ►nih.gov J Wang, T Takeuchi, S Tanaka, SK Kubo, T … - Journal of Clinical Investigation, 1999 - Am Soc Clin Investig The mouse autosomal dominant mutation Mody develops hyperglycemia with notable
pancreatic β-cell dysfunction. This study demonstrates that one of the alleles
of the gene for insulin 2 in Mody mice encodes a protein product that ... Cited by 135 - Related articles - BL Direct - All 10 versions
T Yoshinaga, K Nakatome, J Nozaki, M Naitoh … - Biological Chemistry, 2005 - reference-global.com 1 Department of Health and Environmental Sciences, Kyoto University Graduate
School of Medicine, Kyoto 606-8501, Japan 2 Department of Molecular and Cellular
Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto ... Cited by 9 - Related articles - BL Direct - All 6 versions
- ►fasebj.org C Zuber, JY Fan, B Guhl, J Roth - The FASEB Journal, 2004 - FASEB Figure 1. Fine structural details of ß cells of islets of Langerhans from
control and Akita mice. A) In control mice ß cells, narrow cisternae of rough
endoplasmic reticulum (RER) are continuous (arrowheads) with dilated ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] M Liu, Y Li, D Cavener, P Arvan - Journal of Biological Chemistry, 2005 - ASBMB Upon nonreducing Tris-Tricine-urea-SDS-PAGE, newly synthesized proinsulin from
pancreatic islets of normal rodents forms a band fast mobility representing the
native disulfide isomer, which is efficiently secreted. In addition at ... Cited by 14 - Related articles - All 6 versions
M Collinet, M Berthelon, P Bénit, K Laborde, … - European journal of pediatrics, 1998 - Springer Abstract Familial hyperproinsulinaemia is a rare genetic disorder characterized
by point mutations in the insulin gene which impair the conversion of proinsulin
to insulin. We report here three members of a two-generation Caucasian ... Cited by 5 - Related articles - BL Direct - All 3 versions
C Choeiri, K Hewitt, J Durkin, CJ Simard, JM … - Behavioural Brain Research, 2005 - Elsevier Ins2 C96Y Akita mice represent a model of spontaneous early-onset diabetes
mellitus, expressing a mutant non-functional isoform of insulin. These mice are
characterized by a reduced number of pancreatic β cells resulting in ... Cited by 8 - Related articles - All 2 versions
I Flechtner, M Vaxillaire, H Cav├®, R … - Endocrine development, 2007 - content.karger.com Shield JPH, Scharfmann R (eds): Development of the Pancreas and Neonatal
Diabetes. Endocr Dev. Basel, Karger, 2007, vol 12, pp 86–98 ... Abstract
ATP-sensitive potassium (K ATP ) channels regulate the flux of K + ions ... Cited by 8 - Related articles - BL Direct - All 4 versions
