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Scholar Results 1 - 10 of about 101 related to Aasum: Age-dependent changes in metabolism, contractile function, and ischemic sensitivity.... (0.11 sec) 

Age-dependent changes in metabolism, contractile function, and ischemic sensitivity in …

- diabetesjournals.org
E Aasum, AD Hafstad, DL Severson, TS … - Diabetes, 2003 - Am Diabetes Assoc
Glucose and palmitate metabolism and contractile function were measured with ex
vivo perfused working hearts from control (db/+) and diabetic (db/db) female
mice at 6, 10–12, and 16–18 weeks of age. Palmitate oxidation was ...
Cited by 102 - Related articles - BL Direct - All 4 versions

Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice

- physiology.org
DD Belke, TS Larsen, EM Gibbs, DL Severson - American Journal of Physiology- Endocrinology And …, 2000 - Am Physiological Soc
Contractile function and substrate metabolism were characterized in perfused
hearts from genetically diabetic C57BL/KsJ-lepr db /lepr db (db/db) mice and
their non-diabetic lean littermates. Contractility was assessed in working ...
Cited by 183 - Related articles - BL Direct - All 3 versions

Cardiac function and metabolism in Type 2 diabetic mice after treatment with BM 17.0744, a …

- physiology.org
E Aasum, DD Belke, DL Severson, RA … - American Journal of Physiology- Heart and Circulatory …, 2002 - Am Physiological Soc
Hearts from diabetic db/db mice, a model of Type 2 diabetes, exhibit left
ventricular failure and altered metabolism of exogenous substrates. Peroxisome
proliferator-activated receptor- (PPAR- ) ligands reduce plasma lipid and ...
Cited by 90 - Related articles - BL Direct - All 6 versions

Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice

- shouxi.net
OJ How, E Aasum, DL Severson, WY Chan, … - Diabetes, 2006 - Am Diabetes Assoc
Altered cardiac metabolism and function (diabetic cardiomyopathy) has been
observed in diabetes. We hypothesize that cardiac efficiency, the ratio of
cardiac work (pressure-volume area [PVA]) and myocardial oxygen consumption ...
Cited by 57 - Related articles - BL Direct - All 5 versions

Echocardiographic assessment of cardiac function in diabetic db/db and transgenic db/db …

- physiology.org [PDF] 
LM Semeniuk, AJ Kryski, DL Severson - American Journal of Physiology- Heart and Circulatory …, 2002 - Am Physiological Soc
42 articles, 23 of which you can access free at: This article cites
http://ajpheart.physiology.org/cgi/content/full/283/3/H976#BIBL ... 31 other
HighWire hosted articles, the first 5 are: This article has been cited by
Cited by 87 - Related articles - BL Direct - All 3 versions

Treatment of type 2 diabetic db/db mice with a novel PPAR {gamma} agonist improves cardiac …

- physiology.org
AN Carley, LM Semeniuk, Y Shimoni, E Aasum … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc
Hearts from insulin-resistant type 2 diabetic db/db mice exhibit features of a
diabetic cardiomyopathy with altered metabolism of exogenous substrates and
reduced contractile performance. Therefore, the effect of chronic oral ...
Cited by 59 - Related articles - BL Direct - All 5 versions

Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob …


PK Mazumder, BT O'Neill, MW Roberts, J … - Diabetes, 2004 - Am Diabetes Assoc
Diabetes alters cardiac substrate metabolism. The cardiac phenotype in
insulin-resistant states has not been comprehensively characterized. The goal of
these studies was to determine whether the hearts of leptin-deficient ...
Cited by 99 - Related articles - BL Direct - All 6 versions

Fatty acid metabolism is enhanced in type 2 diabetic hearts


AN Carley, DL Severson - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier
The metabolic phenotype of hearts has been investigated using rodent models of
type 2 diabetes which exhibit obesity and insulin resistance: db/db and ob/ob
mice, and Zucker fatty and ZDF rats. In general, cardiac fatty acid (FA) ...
Cited by 73 - Related articles - All 3 versions

Impact of altered substrate utilization on cardiac function in isolated hearts from Zucker …

- physiology.org
P Wang, SG Lloyd, H Zeng, A Bonen, JC … - American Journal of Physiology- Heart and Circulatory …, 2005 - Am Physiological Soc
The goal of this study was to determine whether changes in cardiac metabolism in
Type 2 diabetes are associated with contractile dysfunction or impaired response
to ischemia. Hearts from Zucker diabetic fatty (ZDF) and lean control rats ...
Cited by 39 - Related articles - BL Direct - All 4 versions

Chylomicron and palmitate metabolism by perfused hearts from diabetic mice

- physiology.org
AS Neitzel, AN Carley, DL Severson - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc
Hydrolysis of triacylglycerols (TG) in circulating chylomicrons by
endothelium-bound lipoprotein lipase (LPL) provides a source of fatty acids (FA)
for cardiac metabolism. The effect of diabetes on the metabolism of ...
Cited by 29 - Related articles - BL Direct - All 5 versions


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