- ►diabetesjournals.org RC Bonadonna, M Stumvoll, A Fritsche, M Muggeo, H … - Diabetes, 2003 - Am Diabetes Assoc We adapted a minimal model to assess β-cell function during a hyperglycemic glucose clamp
and to uncover peculiar aspects of the relationship among β-cell function, plasma glucose, and
insulin sensitivity (IS) in offspring of Caucasian patients with type 2 diabetes (OfT2D). We ... Cited by 46 - Related articles - BL Direct - All 6 versions
A Cretti, M Lehtovirta, E Bonora, B Brunato … - European Journal of …, 2001 - interscience.wiley.com DesignFifty-six subjects were studied. A minimal analogic model of β-cell secretion during the
OGTT was applied to all OGTTs (see below). The amount of insulin secreted over 120' in response
to oral glucose (OGTT-ISR; Insulin Units 120' −1 m −2 BSA) and an index of β-cell ... Cited by 43 - Related articles - BL Direct - All 4 versions
GM Steil, C Hwu, R Janowski, F Hariri, S Jinagouda, C … - Diabetes, 2004 - Am Diabetes Assoc Modeling analysis of glucose, insulin, and C-peptide following a meal has been proposed as
a means to estimate insulin sensitivity (S i ) and β-cell function from a single test. We compared
the model-derived meal indexes with analogous indexes obtained from an intravenous ... Cited by 25 - Related articles - BL Direct - All 4 versions
A Mari - Current Opinion in Clinical Nutrition & Metabolic Care, 2002 - journals.lww.com Recent findings: For the assessment of insulin sensitivity and β-cell function, several modeling
methods have recently been developed. Models for insulin sensitivity provide insulin-sensitivity
indices from simple clinical tests, or a rich multiple-parameter characterization of insulin ... Cited by 27 - Related articles - BL Direct - All 4 versions
G Toffolo, F De Grandi, C Cobelli - Diabetes, 1995 - Am Diabetes Assoc Parametric models of insulin secretion are used to measure indexes of beta-cell function from
plasma C-peptide concentration during an intravenous glucose tolerance test (IVGTT). Since
the models have been usually assessed against plasma C-peptide data, both secretory ... Cited by 57 - Related articles - BL Direct - All 4 versions
G Toffolo, WT Cefalu, C Cobelli - Metabolism, 1999 - Elsevier The insulin-modified intravenous glucose tolerance test (IM-IVGTT) is increasingly used to measure
insulin sensitivity. However, the assessment of β-cell secretion is usually made using rough
indices. The aim here is to evaluate the ability of the minimal model of C-peptide ... Cited by 14 - Related articles - BL Direct - All 4 versions
SD Mittelman, GW Van Citters, SP Kim, DA Davis, MK … - Diabetes, 2000 - Am Diabetes Assoc Central adiposity is highly correlated with insulin resistance, which is an important risk factor
for type 2 diabetes and other chronic diseases. However, in normal individuals, central adiposity
can be tolerated for many years without development of impaired glucose toler- ance or ... Cited by 80 - Related articles - BL Direct - All 7 versions
M Lehtovirta, J Kaprio, L Groop, M Trombetta, RC … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 1604–1613 DOI 10.1007/s00125-005-1815-2 ARTICLE M.
Lehtovirta . J. Kaprio . L. Groop . M. Trombetta . RC Bonadonna Heritability of model-derived
parameters of beta cell secretion during intravenous and oral glucose tolerance tests: ... Cited by 4 - Related articles - BL Direct - All 5 versions
A Mari, B Ahrén, G Pacini - Current Opinion in Clinical Nutrition & …, 2005 - journals.lww.com Purpose of review: In healthy individuals, upregulation of insulin secretion compensates for insulin
resistance so that normal glucose tolerance is maintained. Thus insulin secretion should be evaluated
in relation to insulin sensitivity, as failure to account for insulin resistance may prevent the ... Cited by 22 - Related articles - BL Direct - All 3 versions
- ►endojournals.org R Hovorka, L Chassin, SD Luzio, R Playle, DR … - Journal of Clinical …, 1998 - Endocrine Soc A model-based method was developed to quantify pancreatic ß-cell responsiveness during a
meal tolerance test (MTT). C peptide secretion was related in a linear fashion to glucose
concentration, whereas the standard population model was used to derive transfer rate ... Cited by 40 - Related articles - BL Direct - All 5 versions
