V Asnaghi, C Gerhardinger, T Hoehn, A Adeboje, M … - Diabetes, 2003 - Am Diabetes Assoc We tested the hypothesis that the apoptosis of inner retina neurons and increased expression
of glial fibrillary acidic protein (GFAP) observed in the rat after a short duration of diabetes are
mediated by polyol pathway activity. Rats with 10 weeks of streptozotocin-induced ... Cited by 105 - Related articles - BL Direct - All 4 versions
- ►iovs.org PM Martin, P Roon, TK Van Ells, V Ganapathy, SB … - … ophthalmology & visual …, 2004 - ARVO RESULTS. Morphometric analysis of retinal cross sections of mice that had been diabetic 14
weeks showed 20% to 25% fewer cells in the ganglion cell layer compared with age-matched
control mice. There was a modest, but significant, decrease in the thickness of the whole ... Cited by 84 - Related articles - BL Direct - All 3 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell types when intracellular
glucose concentrations are high, and it can generate cellular stress through several
mechanisms. The role of the polyol pathway in the pathogenesis of diabetic retinopathy ... Cited by 65 - Related articles - BL Direct - All 4 versions
VACGT Hoehn, A Adeboje, M Lorenzi - 糖尿病学杂志, 2003 - journal.shouxi.net We tested the hypothesis that the apoptosis of inner retina neurons and increased expression
of glial fibrillary acidic protein (GFAP) observed in the rat after a short duration of diabetes are
mediated by polyol pathway activity. Rats with 10 weeks of streptozotocin-induced ... Related articles - Cached
- ►nih.gov [PDF] AJ Barber, E Lieth, SA Khin, DA Antonetti, … - Journal of Clinical …, 1998 - pubmedcentral.nih.gov This study determined whether retinal degeneration during diabetes includes retinal neural cell
apoptosis. Image analy- sis of retinal sections from streptozotocin (STZ) diabetic rats after 7.5
months of STZ diabetes identified 22% and 14% reductions in the thickness of the inner ... Cited by 339 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org [PDF] M Mizutani, C Gerhardinger, M Lorenzi - Diabetes, 1998 - Am Diabetes Assoc Vascular cells may not be the only cells affected by dia- betes in the retina. In particular, abnormalities
of the b-wave of the electroretinogram in diabetic patients with absent or minimal microangiopathy
have pointed to possible dysfunction of Müller cells, the principal glia of the retina. In this ... Cited by 160 - Related articles - BL Direct - All 4 versions
E Lieth, AI Barber, B Xu, C Dice, MJ Ratz, D … - DIABETES-NEW …, 1998 - Am Diabetes Assoc The early pathophysiology of diabetic retinopathy and the involvement of neural and vascular
malfunction are poorly understood. Glial cells provide structural and metabolic support for retinal
neurons and blood vessels, and the cells become reactive in certain injury states. We ... Cited by 155 - Related articles - BL Direct - All 4 versions
SH Park, JW Park, SJ Park, KY Kim, JW Chung, MH … - Diabetologia, 2003 - Springer Aims/hypothesis. Neurodegenerative changes in the diabetic retina occurring before diabetic
retinopathy could be inevitable by the altered energy (glucose) metabolism, in the sense that
dynamic image-process- ing activity of the retinal neurons is exclusively de- pendent on ... Cited by 82 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] HP Hammes, HJ Federoff, M Brownlee - Molecular Medicine, 1995 - pubmedcentral.nih.gov Background: Chronic diabetes causes structural changes in theretinal capillaries of nearly all
patients with a disease duration of more than 15 years. Acellular occluded vessels cause
hypoxia, which stimulates sight- threatening abnormal angiogenesis in 50% of all type I ... Cited by 81 - Related articles - All 4 versions
- ►iovs.org RA Feit-Leichman, R Kinouchi, M Takeda, Z Fan, S … - … ophthalmology & visual …, 2005 - ARVO RESULTS. There was transient induction of cell apoptosis and caspase-3 activation in retinal
neurons of C57Bl/6 mice within days of diabetes induction. Glial fibrillary acidic protein
(GFAP), a marker of glial activation, likewise was transiently upregulated, seemingly in ... Cited by 36 - Related articles - BL Direct - All 5 versions
