EMD Nielsen, L Hansen, B Carstensen, SM … - Diabetes, 2003 - Am Diabetes Assoc The E23K polymorphism of the pancreatic β-cell ATP-sensitive K + (K ATP )
channel subunit Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites,
and a recent in vitro study of the E23K variant suggests that the ... Cited by 146 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org C Schwanstecher, U Meyer, M … - Diabetes, 2002 - Am Diabetes Assoc E23K, a common single nucleotide polymorphism in K IR 6.2, the pore-forming
subunit of pancreatic β-cell ATP-sensitive K + channels, significantly enhanced
open probability of these channels, thus reducing their sensitivity toward ... Cited by 124 - Related articles - BL Direct - All 18 versions
L Love-Gregory, J Wasson, J Lin, G Skolnick, … - Diabetologia, 2003 - Springer 2. Wren A, Seal L, Cohen M et al. (2001) Ghrelin enhances appetite and increases
food intake in humans. J Clin Endo- crinol Metab 86: 5992–5995 3. Tschop M,
Weyer C, Tataranni P, Devanarayan V, Ravussin E, Heiman M (2001) ... Cited by 70 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org AL Gloyn, MN Weedon, KR Owen, MJ Turner, BA … - Diabetes, 2003 - Am Diabetes Assoc The genes ABCC8 and KCNJ11, which encode the subunits sulfonylurea receptor 1
(SUR1) and inwardly rectifying potassium channel (Kir6.2) of the β-cell
ATP-sensitive potassium (K ATP ) channel, control insulin secretion. Common ... Cited by 326 - Related articles - All 7 versions
EH Hani, P Boutin, E Durand, H Inoue, MA … - Diabetologia, 1998 - Springer It is widely accepted that Type II (non-insulin depen- dent) diabetes mellitus
is a polygenic disorder charac- terized by chronic hyperglycaemia, with both
genes and environmental factors contributing to the disease development. ... Cited by 165 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Florez, N Burtt, PIW de Bakker, P Almgren, … - Diabetes, 2004 - Am Diabetes Assoc The genes for the sulfonylurea receptor (SUR1; encoded by ABCC8) and its
associated islet ATP-sensitive potassium channel (Kir6.2; encoded by KCNJ11) are
adjacent to one another on human chromosome 11. Multiple studies have ... Cited by 147 - Related articles - BL Direct - All 7 versions
AL Gloyn, Y Hashim, SJH Ashcroft, R Ashfield, … - Diabetic Medicine, 2001 - interscience.wiley.com Aims The beta-cell ATP-sensitive potassium channel consists of two subunits,
SUR1 and Kir6.2. Population association studies have shown that three variants
in SUR1 and one in Kir6.2 are associated with Type 2 diabetes. These ... Cited by 76 - Related articles - BL Direct - All 5 versions
H Sakura, N Wat, V Horton, H Millns, RC … - Diabetologia, 1996 - Springer Summary The ATP-sensitive K-channel plays a cen- tral role in insulin release
from pancreatic beta cells. This channel consists of two subunits: a sulphonyl-
urea receptor, SUR1, and an inwardly rectifying K- channel subunit, Kir6.2. ... Cited by 71 - Related articles - BL Direct - All 3 versions
I Barroso, RPS Jian'an Luan, AHH Middelberg … - PLoS Biology, 2003 - pubmedcentral.nih.gov Type 2 diabetes is an increasingly common, serious metabolic disorder with a
substantial inherited component. It is characterised by defects in both insulin
secretion and action. Progress in identification of specific genetic ... Cited by 165 - Related articles - All 5 versions
EMDNL Hansen, BC Sø - 糖尿病学杂志, 2003 - journal.shouxi.net The E23K polymorphism of the pancreatic ß-cell ATP-sensitive K + (K ATP )
channel subunit Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites,
and a recent in vitro study of the E23K variant suggests that the ... Related articles - Cached
