DB Ring, KW Johnson, EJ Henriksen, JM Nuss … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance plays a central role in the development of type 2 diabetes,
but the precise defects in insulin action remain to be elucidated. Glycogen
synthase kinase 3 (GSK-3) can negatively regulate several aspects of ... Cited by 104 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org GW Cline, K Johnson, W Regittnig, P Perret, … - Diabetes, 2002 - Am Diabetes Assoc Defects in liver and muscle glycogen synthesis are major factors contributing to
postprandrial hyperglycemia in patients with type 2 diabetes. Therefore,
activation of glycogen synthase through inhibition of glycogen synthase ... Cited by 101 - Related articles - BL Direct - All 4 versions
SE Nikoulina, TP Ciaraldi, S Mudaliar, L … - Diabetes, 2002 - Am Diabetes Assoc Glycogen synthase kinase (GSK)-3 has been implicated in the regulation of
multiple cellular physiological processes in skeletal muscle. Selective
cell-permeable reversible inhibitors (INHs) of GSK-3 (CT98014 and CHIR98023 ... Cited by 81 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] SE Nikoulina, TP Ciaraldi, S Mudaliar, P … - Diabetes, 2000 - Am Diabetes Assoc Glycogen synthase (GS) activity is reduced in skeletal muscle of type 2
diabetes, despite normal protein expression, consistent with altered GS
regulation. Glycogen synthase kinase-3 (GSK-3) is involved in reg- ulation ( ... Cited by 156 - Related articles - BL Direct - All 5 versions
- ►physiology.org EJ Henriksen, TR Kinnick, MK Teachey, MP O … - American Journal of Physiology- Endocrinology And …, 2003 - Am Physiological Soc A role for elevated glycogen synthase kinase-3 (GSK-3) activity in the
multifactorial etiology of insulin resistance is now emerging. However, the
utility of specific GSK-3 inhibition in modulating insulin resistance of ... Cited by 57 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org [PDF] H Eldar-Finkelman, SA Schreyer, MM … - Diabetes, 1999 - Am Diabetes Assoc Although the precise mechanisms contributing to insu- lin resistance and type 2
diabetes are unknown, it is believed that defects in downstream components of
the insulin signaling pathway may be involved. In this work, we hypothesize ... Cited by 107 - Related articles - BL Direct - All 5 versions
AS Wagman, KW Johnson, DE Bussiere - Current pharmaceutical design, 2004 - ingentaconnect.com Abstract: Originally identified as a modulator of glycogen metabolism, glycogen
synthase kinase-3 (GSK3) is now understood to play an important regulatory role
in a variety of pathways including initiation of protein synthesis, cell ... Cited by 76 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org B Plotkin, O Kaidanovich, I Talior, H Eldar- … - Journal of Pharmacology and Experimental …, 2003 - ASPET Glycogen synthase kinase-3 (GSK-3) was shown to be a key factor in attenuation
of the cellular action of insulin. We speculated that inhibition of GSK-3 might
have a potential therapeutic value in treatment of insulin resistance and ... Cited by 63 - Related articles - BL Direct - All 4 versions
NJ Pearce, JRS Arch, JC Clapham, MP Coghlan … - Metabolism, 2004 - Elsevier Glycogen synthase kinase-3 (GSK-3) protein levels and activity are elevated in
skeletal muscle in type 2 diabetes, and inversely correlated with both glycogen
synthase activity and insulin-stimulated glucose disposal. To explore this ... Cited by 39 - Related articles - All 4 versions
K MacAulay, E Hajduch, AS Blair, MP … - European Journal of Biochemistry, 2003 - interscience.wiley.com Glycogen synthase kinase 3 (GSK3) is inactivated by insulin and lithium and,
like insulin, Li also activates glycogen synthase (GS) via inhibition of GSK3.
Li also mimics insulin's ability to stimulate glucose transport (GT), an ... Cited by 48 - Related articles - BL Direct - All 6 versions
