- ►diabetesjournals.org M Delibegovic, CG Armstrong, L Dobbie, PW Watt, AJH … - Diabetes, 2003 - Am Diabetes Assoc Disruption of the PPP1R3A gene encoding the glycogen targeting subunit (G M /R GL ) of protein
phosphatase 1 (PP1) causes substantial lowering of the glycogen synthase activity and a
10-fold decrease in the glycogen levels in skeletal muscle. Homozygous G M −/− mice ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►nih.gov SM Crosson, A Khan, J Printen, JE Pessin, … - Journal of Clinical …, 2003 - Am Soc Clin Investig Protein targeting to glycogen (PTG) is a scaffolding protein that targets protein phosphatase 1α
(PP1α) to glycogen, and links it to enzymes involved in glycogen synthesis and degradation.
We generated mice that possess a heterozygous deletion of the PTG gene. These mice ... Cited by 33 - Related articles - BL Direct - All 12 versions
- ►nih.gov Y Suzuki, C Lanner, JH Kim, PG Vilardo, H … - Molecular and Cellular …, 2001 - Am Soc Microbiol The regulatory-targeting subunit (R GL , also called G M ) of the muscle-specific glycogen-associated
protein phosphatase PP1G targets the enzyme to glycogen where it modulates the activity of
glycogen-metabolizing enzymes. PP1G/R GL has been postulated to play a central role in ... Cited by 71 - Related articles - BL Direct - All 7 versions
S Munro, DJR Cuthbertson, J Cunningham, M Sales, … - Diabetes, 2002 - Am Diabetes Assoc Insulin has been previously shown to regulate the expression of the hepatic glycogen-targeting
subunit, G L , of protein phosphatase 1 (PP1) and is believed to control the activity of the
PP1-G L complex by modulation of the level of phosphorylase a, which allosterically ... Cited by 23 - Related articles - BL Direct - All 5 versions
C Lannér, Y Suzuki, C Bi, H Zhang, LD Cooper, MM … - Archives of Biochemistry …, 2001 - Elsevier The type I phosphatase associated with glycogen, PP1G, plays an important role in glycogen
metabolism. PP1G is targeted to glycogen by the R GL subunit, which regulates the function
of the enzyme. We report the cloning and characterization of the gene as well as the ... Cited by 9 - Related articles - BL Direct - All 3 versions
- ►jbc.org C Lerin, E Montell, HK Berman, CB Newgard, AM … - Journal of Biological …, 2000 - ASBMB There is growing evidence that glycogen targeting subunits of protein phosphatase-1 play a
critical role in regulation of glycogen metabolism. In the current study, we have investigated the
effects of adenovirus-mediated overexpression of a specific glycogen targeting subunit ... Cited by 19 - Related articles - BL Direct - All 3 versions
- ►jbc.org R Gasa, C Clark, R Yang, AA DePaoli-Roach, CB … - Journal of Biological …, 2002 - ASBMB Glycogen-targeting subunits of protein phosphatase-1 facilitate interaction of the phosphatase
with enzymes of glycogen metabolism. Expression of one family member, PTG, in the liver of
normal rats improves glucose tolerance without affecting other plasma variables but ... Cited by 16 - Related articles - BL Direct - All 5 versions
- ►jbc.org NM Fong, TC Jensen, AS Shah, NN Parekh, AR … - Journal of Biological …, 2000 - ASBMB The activation of protein phosphastase-1 (PP1) by insulin plays a critical role in the regulation
of glycogen metabolism. PTG is a PP1 glycogen-targeting protein, which also binds the PP1
substrates glycogen synthase, glycogen phosphorylase, and phosphorylase kinase ... Cited by 33 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] GJ Browne, M Delibegovic, S Keppens, W … - Biochemical …, 2001 - pubmedcentral.nih.gov Gareth J. BROWNE*1, Mirela DELIBEGOVIC*1, Stefaan KEPPENS†, Willy STALMANS† and
Patricia TW COHEN*2 *MRC Protein Phosphorylation Unit, School of Life Sciences, MSI/WTB
Complex, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, UK, and † ... Cited by 24 - Related articles - BL Direct - All 10 versions
- ►jbc.org R Yang, L Cao, R Gasa, MJ Brady, AD Sherry, CB … - Journal of Biological …, 2002 - ASBMB Overexpression of the glucose-phosphorylating enzyme glucokinase (GK) or members of the
family of glycogen-targeting subunits of protein phosphatase-1 increases hepatic glucose disposal
and glycogen synthesis. This study was undertaken to evaluate the functional properties ... Cited by 26 - Related articles - BL Direct - All 5 versions
