- ►diabetesjournals.org H Daitoku, K Yamagata, H Matsuzaki, M Hatta … - Diabetes, 2003 - Am Diabetes Assoc Peroxisome proliferator–activated receptor-γ coactivator-1 (PGC-1) plays a
major role in mediating hepatic gluconeogenesis in response to starvation,
during which PGC-1 is induced by the cyclic AMP response element binding ... Cited by 129 - Related articles - BL Direct - All 4 versions
D Schmoll, KS Walker, DR Alessi, R Grempler … - Journal of Biological Chemistry, 2000 - ASBMB Glucose-6-phosphatase plays an important role in the regulation of hepatic
glucose production, and insulin suppresses glucose-6-phosphatase gene
expression. Recent studies indicate that protein kinase B and Forkhead ... Cited by 156 - Related articles - BL Direct - All 6 versions
P Puigserver, J Rhee, J Donovan, CJ Walkey, … - Nature, 2003 - nature.com Hepatic gluconeogenesis is absolutely required for survival during prolonged
fasting or starvation, but is inappropriately activated in diabetes mellitus.
Glucocorticoids and glucagon have strong gluconeogenic actions on the ... Cited by 146 - Related articles - BL Direct - All 6 versions
- ►pnas.org J Rhee, Y Inoue, JC Yoon, P Puigserver, M … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences The liver plays several critical roles in the metabolic adaptation to fasting.
We have shown previously that the transcriptional coactivator peroxisome
proliferator-activated receptor γ coactivator-1α (PGC-1α) is induced in ... Cited by 223 - Related articles - BL Direct - All 7 versions
S Herzig, F Long, US Jhala, S Hedrick, R … - Nature, 2001 - nature.com When mammals fast, glucose homeostasis is achieved by triggering expression of
gluconeogenic genes in response to glucagon and glucocorticoids. The pathways
act synergistically to induce gluconeogenesis (glucose synthesis), although ... Cited by 436 - Related articles - BL Direct - All 7 versions
JE Ayala, RS Streeper, JS Desgrosellier, SK … - Diabetes, 1999 - Am Diabetes Assoc Because overexpression of the glucose-6-phosphatase catalytic subunit (G-6-Pase)
in both type 1 and type 2 diabetes may contribute to the characteristic
increased rate of hepatic glucose production, we have investi- gated ... Cited by 73 - Related articles - BL Direct - All 4 versions
- ►jbc.org RK Hall, T Yamasaki, T Kucera, M Waltner- … - Journal of Biological Chemistry, 2000 - ASBMB Winged helix/forkhead (Fox) transcription factors have been implicated in the
regulation of a number of insulin-responsive genes. The insulin response
elements (IREs) of the phosphoenolpyruvate carboxykinase (PEPCK) and ... Cited by 145 - Related articles - BL Direct - All 4 versions
- ►pnas.org MP Czubryt, J McAnally, GI Fishman, EN … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences The myocyte enhancer factor-2 (MEF2) transcription factor regulates muscle
development and calcium-dependent gene expression. MEF2 activity is repressed by
class II histone deacetylases (HDACs), which dissociate from MEF2 when ... Cited by 158 - Related articles - BL Direct - All 6 versions
K Hirota, H Daitoku, H Matsuzaki, N Araya, … - Journal of Biological Chemistry, 2003 - ASBMB Previous studies have shown that FKHR, a member of the forkhead family of
transcription factors, acts as a DNA binding-independent cofactor of nuclear
receptors, including estrogen, retinoid, and thyroid hormone receptors, in ... Cited by 67 - Related articles - BL Direct - All 4 versions
