SA Phillips, TP Ciaraldi, APS Kong, R Bandukwala, V … - Diabetes, 2003 - Am Diabetes Assoc The relationship between insulin action and control of the adipocyte-derived factor adiponectin
was studied in age- and weight-matched obese individuals with type 2 diabetes failing sulfonylurea
therapy. After initial metabolic characterization, subjects were randomized to troglitazone ... Cited by 163 - Related articles - BL Direct - All 6 versions
JG Yu, S Javorschi, AL Hevener, YT Kruszynska, RA … - Diabetes, 2002 - Am Diabetes Assoc The insulin-sensitizing effects of thiazolidinediones are thought to be mediated through peroxisome
proliferator-activated receptor-γ, a nuclear receptor that is highly abundant in adipose tissue.
It has been reported that adipocytes secrete a variety of proteins, including tumor necrosis ... Cited by 454 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org J Tonelli, W Li, P Kishore, UB Pajvani, E Kwon, C … - Diabetes, 2004 - Am Diabetes Assoc Whereas thiazolidinediones (TZDs) are known to rapidly improve insulin action in animals, short
durations of TZD therapy have never been studied in humans. Among the many known actions
of TZDs, increased circulating levels of the high molecular weight (HMW) multimer of ... Cited by 143 - Related articles - BL Direct - All 5 versions
H Hirose, T Kawai, Y Yamamoto, M Taniyama, M … - Metabolism, 2002 - Elsevier The aim of this study was to evaluate the effects of pioglitazone on clinical and metabolic
parameters, body fat distribution, and serum adiponectin, a recently discovered antiatherosclerotic
hormone, in Japanese patients with type 2 diabetes. Ten male patients aged 40 to 66 ... Cited by 194 - Related articles - BL Direct - All 7 versions
Y Wang, A Xu, C Knight, LY Xu, GJS Cooper - Journal of Biological Chemistry, 2002 - ASBMB It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease
hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin
is functionally inactive. Here, we show that endogenous adiponectin secreted by ... Cited by 240 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org WS Yang, CY Jeng, TJ Wu, S Tanaka, T Funahashi, … - Diabetes Care, 2002 - Am Diabetes Assoc OBJECTIVE—Adiponectin, a plasma protein exclusively synthesized and secreted by adipose
tissue, has recently been shown to have anti-inflammatory, antiatherogenic properties in vitro
and beneficial metabolic effects in animals. Lower plasma levels of adiponectin have ... Cited by 345 - Related articles - BL Direct - All 5 versions
N Maeda, M Takahashi, T Funahashi, S Kihara, H … - Diabetes, 2001 - Am Diabetes Assoc Insulin resistance and its dreaded consequence, type 2 diabetes, are major causes of
atherosclerosis. Adiponectin is an adipose-specific plasma protein that possesses anti-atherogenic
properties, such as the suppression of adhesion molecule expression in vascular ... Cited by 1017 - Related articles - BL Direct - All 4 versions
O Ukkola, M Santaniemi - Journal of Molecular Medicine, 2002 - Springer Abstract Adiponectin is a novel polypeptide that is high- ly specific to adipose tissue. In contrast
to other adipocy- tokines, adiponectin levels are decreased in obesity and associated
comorbidities, such as type 2 diabetes. De- creased expression of adiponectin is ... Cited by 129 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org M Chandran, SA Phillips, T Ciaraldi, RR Henry - Diabetes Care, 2003 - Am Diabetes Assoc Recent research has shown that adipose tissue is not simply an inert storage depot for lipids
but is also an important endocrine organ that plays a key role in the integration of endocrine,
metabolic, and inflammatory signals for the control of energy homeostasis. The adipocyte ... Cited by 393 - Related articles - BL Direct - All 5 versions
