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Scholar Results 1 - 10 of about 101 related to Clegg: Differential sensitivity to central leptin and insulin in male and female rats. (0.10 sec) 

Differential sensitivity to central leptin and insulin in male and female rats


DJ Clegg, CA Riedy, KAB Smith, SC Benoit, … - Diabetes, 2003 - Am Diabetes Assoc
The distribution of fat in the body differs between the male and female sexes
and is associated with the relative secretion of the two “adiposity”
hormones leptin and insulin. We now report that the brains of male and ...
Cited by 82 - Related articles - BL Direct - All 5 versions

Gonadal hormones determine sensitivity to central leptin and insulin

- diabetesjournals.org
DJ Clegg, LM Brown, SC Woods, SC Benoit - Diabetes, 2006 - Am Diabetes Assoc
Males have proportionally more visceral fat and are more likely to develop
complications associated with obesity than females, and the male brain is
relatively more sensitive to the catabolic action of insulin and less ...
Cited by 83 - Related articles - BL Direct - All 5 versions

Intranasal insulin reduces body fat in men but not in women

- universit%c3%a4t-l%c3%bcbeck.de [PDF] 
M Hallschmid, C Benedict, B Schultes, HL … - Diabetes, 2004 - Am Diabetes Assoc
Insulin acts in the central nervous system to reduce food intake and body weight
and is considered a major adiposity signal. After intranasal administration,
insulin enters the cerebrospinal fluid compartment and alters brain ...
Cited by 59 - Related articles - BL Direct - All 10 versions

Insulin as an adiposity signal.


SC Woods, RJ Seeley - International journal of obesity and related metabolic …, 2001 - ncbi.nlm.nih.gov
Insulin is now well established as an adiposity signal that acts in the brain to
influence energy homeostasis. It is secreted in direct proportion to adiposity;
it enters the brain from the blood, and it interacts with neurons in the ...
Cited by 45 - Related articles - BL Direct

The catabolic action of insulin in the brain is mediated by melanocortins

- jneurosci.org
SC Benoit, EL Air, LM Coolen, R Strauss, A … - Journal of Neuroscience, 2002 - Soc Neuroscience
Like leptin, the pancreatic hormone insulin is an important adiposity signal to
the brain. We report that the hypothalamic melanocortin system is an important
target of the actions of insulin to regulate food intake and body weight. ...
Cited by 142 - Related articles - BL Direct - All 8 versions

Insulin and the blood-brain barrier


SC Woods, RJ Seeley, DG Baskin, MW … - Current pharmaceutical design, 2003 - ingentaconnect.com
Abstract: Although several possible mechanisms exist by which the pancreatic
hormone, insulin, could enter the brain from the blood, most evidence suggests
that the majority of it enters primarily by a receptor-mediated transport ...
Cited by 85 - Related articles - BL Direct - All 3 versions

Gender differences in the control of energy homeostasis

- ebmonline.org
SC Woods, K Gotoh, DJ Clegg - Experimental Biology and Medicine, 2003 - SEBM
The world is experiencing an epidemic of obesity and its concomitant health
problems. One implication is that the normally robust negative feedback system
that controls energy homeostasis must be responding to different inputs ...
Cited by 51 - Related articles - BL Direct - All 3 versions

Cyclic estradiol treatment normalizes body weight and restores physiological patterns of …


L Asarian, N Geary - Hormones and Behavior, 2002 - Elsevier
Hypothalamic–pituitary–gonadal axis function strongly influences feeding and
body weight in cycling females in many species. To test the sufficiency of
cyclic variations in plasma estradiol to reproduce normal patterns of ...
Cited by 67 - Related articles - BL Direct - All 4 versions

Insulin and leptin combine additively to reduce food intake and body weight in rats

- endojournals.org [PDF] 
EL Air, SC Benoit, DJ Clegg, RJ Seeley, SC … - Endocrinology, 2002 - Endocrine Soc
2450 Endocrinology, June 2002, 143(6):2449-2452 Air et al. • Rapid
Communications injection were determined to have correct placement and were
included in the studies. All procedures were approved by the University of ...
Cited by 69 - Related articles - BL Direct - All 4 versions

Estrogen deficiency causes central leptin insensitivity and increased hypothalamic …


DA Ainslie, MJ Morris, G Wittert, H Turnbull, J … - International journal of obesity and related metabolic …, 2001 - ncbi.nlm.nih.gov
1: Int J Obes Relat Metab Disord. 2001 Nov;25(11):1680-8. Estrogen deficiency causes
central leptin insensitivity and increased hypothalamic neuropeptide Y. ...
Cited by 70 - Related articles - BL Direct - All 3 versions


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