K Maedler, J Oberholzer, P Bucher, GA Spinas, MY … - Diabetes, 2003 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2
diabetes. Here we examine the effect of saturated and monounsaturated fatty acids at different
glucose concentrations on human β-cell turnover and secretory function. Exposure of ... Cited by 150 - Related articles - BL Direct - All 5 versions
K Maedler, GA Spinas, D Dyntar, W Moritz, N Kaiser, … - Diabetes, 2001 - Am Diabetes Assoc Glucotoxicity and lipotoxicity contribute to the impaired β-cell function observed in type 2
diabetes. Here we examine the effect of saturated and unsaturated fatty acids at different glucose
concentrations on β-cell proliferation and apoptosis. Adult rat pancreatic islets were ... Cited by 223 - Related articles - BL Direct - All 7 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R Roduit, S … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty acids (FFAs)
together with hyperglycemia are synergistic in causing islet ß-cell damage because high glucose
inhibits fat oxidation and consequently lipid detoxification. The effects of 1–2 d culture of ... Cited by 174 - Related articles - BL Direct - All 5 versions
- ►endojournals.org E Karaskov, C Scott, L Zhang, T Teodoro, M Ravazzola, … - Endocrinology, 2006 - Endocrine Soc Chronic free fatty acid (FFA) exposure induces pancreatic ß-cell death, which may contribute
to the development of type 2 diabetes. The mechanisms involved in FFA-induced cell death are
not completely understood. Here we have investigated the effect of FFA on endoplasmic ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►endojournals.org I Maestre, J Jordan, S Calvo, JA Reig, V Cena, B Soria, … - Endocrinology, 2003 - Endocrine Soc The potential toxic effects of high extracellular concentrations of fatty acids were tested in
ß(INS-1)-cells cultured in the absence of serum, a condition known to alter cell survival in various
systems. This may in part mimic the situation in type 1 or 2 diabetes where ß-cells are ... Cited by 82 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org M Cnop, JC Hannaert, A Hoorens, DL Eizirik, DG … - Diabetes, 2001 - Am Diabetes Assoc Studies in Zucker diabetic fatty rats have led to the concept that chronically elevated free fatty
acid (FFA) levels can cause apoptosis of triglyceride-laden pancreatic β-cells as a result of the
formation of ceramides, which induce nitric oxide (NO)-dependent cell death. This “ ... Cited by 219 - Related articles - BL Direct - All 9 versions
AK Busch, E Gurisik, DV Cordery, M Sudlow, GS … - Diabetes, 2005 - Am Diabetes Assoc Increased availability of fatty acids causes cell death and dysfunction in β-cell lines, isolated
islets, and animal models of diabetes. From the MIN6 β-cell line, we selected two subpools that
are resistant to palmitate-induced apoptosis. Protection was not universal because ... Cited by 40 - Related articles - BL Direct - All 5 versions
K Eitel, H Staiger, MD Brendel, D Brandhorst, RG … - … and Biophysical Research …, 2002 - Elsevier It is believed that free fatty acids contribute to the pathogenesis of type 2 diabetes in
humans. We have recently shown that lipoapoptosis of human β-cells is specifically induced
by saturated fatty acids while unsaturated had no effect. In the present study we tested the ... Cited by 42 - Related articles - All 6 versions
R Lupi, F Dotta, L Marselli, S Del Guerra, M Masini, C … - Diabetes, 2002 - Am Diabetes Assoc In an effort to better understand the phenomenon of lipotoxicity in human β-cells, we evaluated
the effects of 48-h preculture with 1.0 or 2.0 mmol/l free fatty acid (FFA) (2:1 oleate to
palmitate) on the function and survival of isolated human islets and investigated some of ... Cited by 270 - Related articles - BL Direct - All 7 versions
JH Moffitt, BA Fielding, R Evershed, R Berstan, JM … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Long-term exposure of beta cells to lipids, particularly saturated fatty
acids in vitro, results in cellular dysfunction and apoptosis (lipotoxicity); this could contribute to
obesity-related diabetes. Our aims were to relate cell death to intracellular triglyceride ... Cited by 37 - Related articles - BL Direct - All 3 versions
