T Yokota, RC Ma, JY Park, K Isshiki, KB … - Diabetes, 2003 - Am Diabetes Assoc Increased expression of endothelin-1 (ET-1) is associated with diabetic
retinopathy and vasculopathy, although the molecular explanation has not been
defined. The effects of high glucose and protein kinase C (PKC) activation ... Cited by 53 - Related articles - BL Direct - All 4 versions
C Takagi, SE Bursell, YW Lin, H Takagi, E … - Investigative ophthalmology & visual science, 1996 - ARVO PURPOSE: To investigate the role of endogenous endothelin-1 (ET-1) expression
and its interaction with the ETA receptor in the physiologic regulation of
vascular tone as well as in the development of abnormal retinal ... Cited by 104 - Related articles - BL Direct - All 3 versions
T Abiko, A Abiko, AC Clermont, B Shoelson, N … - Diabetes, 2003 - Am Diabetes Assoc Increases in leukostasis/monocyte adhesion to the capillary endothelium
(leukostasis) and decreases in retinal blood flow may be causally associated and
are implicated in the pathogenesis of diabetic retinopathy. In this study, ... Cited by 84 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org [PDF] JY Park, N Takahara, A Gabriele, E Chou, K … - Diabetes, 2000 - Am Diabetes Assoc Enhanced actions or levels of endothelin-1 (ET-1), a potent vasoconstrictor,
have been associated with decreased blood flow in the retina and peripheral
nerves of diabetic animals and may be related to the develop- ment of ... Cited by 196 - Related articles - BL Direct - All 7 versions
- ►iovs.org A Nonaka, J Kiryu, A Tsujikawa, K Yamashiro … - Investigative ophthalmology & visual science, 2000 - ARVO PURPOSE. The activity of protein kinase C (PKC), preferentially ß isoform of
PKC, has been shown to be elevated in the diabetic retina. Recently, LY333531, a
specific inhibitor of PKC-ß, has been reported to improve the decrease of ... Cited by 64 - Related articles - BL Direct - All 4 versions
- ►iovs.org [PDF] U Chakravarthy, RG Hayes, AW Stitt, A … - Investigative ophthalmology & visual science, 1997 - ARVO Purpose. The endothelins are potent vasoactive peptides that are widely
distributed in ocular tissues. There is evidence linking the endothelins to
vascular dysfunction in diabetic microangi- opathy. Thus, the synthesis and ... Cited by 29 - Related articles - BL Direct - All 4 versions
K Suzuma, N Takahara, I Suzuma, K Isshiki, K … - Proceedings of the National Academy of Sciences, 2002 - National Acad Sciences Retinal neovascularization is a major cause of blindness and requires the
activities of several signaling pathways and multiple cytokines. Activation of
protein kinase C (PKC) enhances the angiogenic process and is involved in ... Cited by 106 - Related articles - BL Direct - All 7 versions
D Deng, T Evans, K Mukherjee, D Downey, S … - Diabetologia, 1999 - Springer Page 1. Endothelins (ETs) are a family of 21 amino acid pep- tides with
diverse biological actions [1±5]. Alteration of ETs are ... Cited by 91 - Related articles - BL Direct - All 4 versions
[CITATION] Extracellular matrix changes in diabetes mellitus
JR Williamson, C Kilo - Comparative pathobiology of major age-related …, 1984 Cited by 32 - Related articles
- ►iovs.org [PDF] SE Bursell, C Takagi, AC Clermont, H Takagi, F … - Investigative ophthalmology & visual science, 1997 - ARVO Purpose. Elevation of diacylglycerol (DAG) and protein kinase C (PKC) levels in
diabetic vascular tissue is associated with abnormalities of retinal and renal
hemodynamics. The object of this study was to determine whether direct ... Cited by 57 - Related articles - BL Direct - All 3 versions
