AD Hodgkinson, T Bartlett, PJ Oates, BA Millward, AG … - Diabetes, 2003 - Am Diabetes Assoc Increased flux of glucose through the polyol pathway may cause generation of excess reactive
oxygen species (ROS), leading to tissue damage. Abnormalities in expression of enzymes that
protect against oxidant damage may accentuate the oxidative injury. The expression of ... Cited by 55 - Related articles - BL Direct - All 4 versions
A Ceriello, A Morocutti, F Mercuri, L … - DIABETES-NEW …, 2000 - Am Diabetes Assoc There is an individual susceptibility to diabetic nephropathy, and oxidative stress is believed
to play an important role in the pathogenesis of diabetic compli- cations. Active oxygen species
induce antioxidant enzyme expression in tissues, an effect considered to be a defensive ... Cited by 93 - Related articles - BL Direct - All 5 versions
A Ceriello, E Motz - The New England journal of medicine, 2002 - ncbi.nlm.nih.gov 1: N Engl J Med. 2002 Feb 28;346(9):705-7. Comment on: N Engl J Med. 2001 Sep
20;345(12):851-60. N Engl J Med. 2001 Sep 20;345(12):861-9. N Engl J Med. 2001 Sep
20;345(12):870-8. Angiotensin-receptor blockers, type 2 diabetes, and renoprotection. ... Cited by 18 - Related articles
B Yang, A Millward, A Demaine - BBA-Molecular Basis of Disease, 2003 - Elsevier Studies have shown that polymorphisms located at positions −106 and approximately −2100
base pairs (5′ALR2) in the regulatory region of the aldose reductase gene are associated with
susceptibility to microvascular complications in patients with diabetes. The aim was to ... Cited by 16 - Related articles - All 4 versions
R Da Ros, R Assaloni, A Ceriello - Diabetic Medicine, 2004 - pt.wkhealth.com Methods: Recent studies show that hyperglycaemia-induced overproduction of superoxide seems
to be the first and key event in activation of pathways involved in the pathogenesis of diabetic
complications. Superoxide overproduction is accompanied by increased nitric oxide ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►iovs.org A Demaine, D Cross, A Millward - Investigative ophthalmology & visual science, 2000 - ARVO PURPOSE. Aldose reductase (ALR2) is the first and rate-limiting enzyme of the polyol pathway
and is involved in the pathogenesis of diabetic retinopathy. Polymorphisms of the ALR2 gene
are associated with susceptibility to diabetic retinopathy in Chinese and Japanese ... Cited by 50 - Related articles - BL Direct - All 5 versions
YL Kao, K Donaghue, A Chan, J Knight, M Silink - Diabetes, 1999 - Am Diabetes Assoc Page 1. 1338 DIABETES, VOL. 48, JUNE 1999 Brief Genetics Report A Novel
Polymorphism in the Aldose Reductase Gene Promoter Region Is Strongly Associated
Wi th Diabetic Retinopathy in Adolescents With Type 1 D iabetes ... Cited by 72 - Related articles - BL Direct - All 4 versions
M Lajer, L Tarnow, J Fleckner, BV Hansen, DG … - Diabetic …, 2004 - interscience.wiley.com Aims The Z−2 allele of the (AC) n polymorphism in the aldose reductase gene (ALR2) confers
increased risk of microvascular diabetic complications, whereas the Z+2 allele has been proposed
to be a marker of protection. However data are conflicting. Therefore, we investigated ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►physiology.org [PDF] J Morrison, K Knoll, MJ Hessner, M … - Physiological Genomics, 2004 - Am Physiological Soc Page 1. Effect of high glucose on gene expression in mesangial cells: Up-regulation
of the thiol pathway is an adaptational response Jolean Morrison 1 , Kristen Knoll
1 , Martin J. Hessner 2, 3 , and Mingyu Liang 1 1 Departments ... Cited by 23 - Related articles - BL Direct - All 4 versions
[CITATION] Effect of polymorphism of (AC) n in the 5′ end of aldose reductase gene on …
