- ►pubget.com [PDF] IG Obrosova, AG Minchenko, R Vasupuram, L … - Diabetes, 2003 - Am Diabetes Assoc The study addressed the role for aldose reductase (AR) in 1) retinal oxidative
stress and vascular endothelial growth factor (VEGF) overexpression in early
diabetes, and 2) high glucose-induced oxidative stress in retinal ... Cited by 83 - Related articles - BL Direct - All 5 versions
Z Dagher, YS Park, V Asnaghi, T Hoehn, C … - Diabetes, 2004 - Am Diabetes Assoc The polyol (sorbitol) pathway of glucose metabolism is activated in many cell
types when intracellular glucose concentrations are high, and it can generate
cellular stress through several mechanisms. The role of the polyol pathway ... Cited by 65 - Related articles - BL Direct - All 4 versions
N Kato, S Yashima, T Suzuki, Y Nakayama, T … - Journal of Diabetes and its Complications, 2003 - Elsevier It is important to suppress retinal vascular changes for prevention of the onset
and progression of diabetic retinopathy. In the present study, we investigated
the dose–response effect of an aldose reductase (AR) inhibitor, ... Cited by 32 - Related articles - All 8 versions
- ►nih.gov IG Obrosova, P Pacher, C Szabó, Z … - Diabetes, 2005 - Am Diabetes Assoc This study evaluated the effects of aldose reductase inhibition on
diabetes-induced oxidative-nitrosative stress and poly(ADP-ribose) polymerase
(PARP) activation. In animal experiments, control and ... Cited by 73 - Related articles - All 8 versions
- ►iovs.org AB El-Remessy, G Abou-Mohamed, RW … - Investigative ophthalmology & visual science, 2003 - ARVO PURPOSE. Analyses in diabetic rats have shown that breakdown of the
blood–retina barrier is associated with increased formation of peroxynitrite,
nitric oxide, and lipid peroxidation. The permeability increase is blocked ... Cited by 55 - Related articles - BL Direct - All 4 versions
- ►physiology.org S Gupta, E Chough, J Daley, P Oates, K … - American Journal of Physiology- Cell Physiology, 2002 - Am Physiological Soc Nitric oxide (NO) plays an important role in the control of numerous vascular
functions including basal Na + -K + -ATPase activity in arterial tissue.
Hyperglycemia inhibits Na + -K + -ATPase activity in rabbit aorta, in part, ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org AKH Cheung, MKL Fung, ACY Lo, TTL Lam, … - Diabetes, 2005 - Am Diabetes Assoc In 15-month-old db/db mice, signs of diabetic retinopathy, including
blood-retinal barrier breakdown, loss of pericytes, neuro-retinal apoptosis,
glial reactivation, and proliferation of blood vessels, were evident. These ... Cited by 50 - Related articles - BL Direct - All 5 versions
- ►fasebj.org [PDF] IG Obrosova, CV Huysen, L Fathallah, X Cao … - The FASEB Journal, 2001 - FASEB The FASEB Journal express article 10.1096/fj.01-0603fje. Published online
November 14, 2001. ... An aldose reductase inhibitor reverses early diabetes- ... Irina G. Obrosova*, Carol Van Huysen*, Lamia Fathallah*, Xianghui ... Cited by 93 - Related articles - BL Direct - All 5 versions
S Amano, S Yamagishi, N Kato, Y Inagaki, T … - Biochemical and Biophysical Research …, 2002 - Elsevier The polyol pathway consists of two enzymes, aldose reductase (AR) and sorbitol
dehydrogenase (SDH). There is a growing body of evidence to suggest that
acceleration of the polyol pathway is implicated in the pathogenesis of ... Cited by 44 - Related articles - BL Direct - All 5 versions
V Asnaghi, C Gerhardinger, T Hoehn, A … - Diabetes, 2003 - Am Diabetes Assoc We tested the hypothesis that the apoptosis of inner retina neurons and
increased expression of glial fibrillary acidic protein (GFAP) observed in the
rat after a short duration of diabetes are mediated by polyol pathway ... Cited by 105 - Related articles - BL Direct - All 4 versions
