DT Robles, GS Eisenbarth, NJM Dailey, LB … - Diabetes, 2003 - Am Diabetes Assoc Susceptibility to diabetes in humans and nonobese diabetic (NOD) mice is
believed to arise from the combined effect of multiple genetic loci, resulting
in immune-mediated destruction of the insulin-secreting β-cells. Insulin ... Cited by 28 - Related articles - BL Direct - All 4 versions
KL Legge, JJ Bell, L Li, JC Caprio, H … - International Reviews of Immunology, 2001 - informahealthcare.com Peripheral tolerance, represents an attractive strategy to down-regulate
previously activated T cells and suppress an ongoing disease. Herein,
immunoglobulins (Igs) were used to deliver self and altered self peptides ... Cited by 14 - Related articles - BL Direct - All 3 versions
T Pearson, P Weiser, TG Markees, DV Serreze … - Diabetes, 2004 - Am Diabetes Assoc NOD mice develop type 1 autoimmune diabetes and exhibit genetically dominant
resistance to transplantation tolerance induction. These two phenotypes are
genetically separable. Costimulation blockade fails to prolong skin ... Cited by 16 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org RK Gregg, JJ Bell, HH Lee, R Jain, SJ … - The Journal of Immunology, 2005 - Am Assoc Immnol IL-10, a powerful anti-Th1 cytokine, has shown paradoxical effects against
diabetes. The mechanism underlying such variable function remains largely
undefined. An approach for controlled mobilization of endogenous IL-10 was ... Cited by 12 - Related articles - All 4 versions
C Faveeuw, MC Gagnerault, F Lepault - Journal of immunological methods, 1995 - Elsevier A simple method was developed for flow cytometric immunofluorescence analysis of
cells infiltrating the islets of Langerhans in diabetes-prone rodents.
Pancreases were submitted to collagenase P digestion and, in order to ... Cited by 15 - Related articles - All 4 versions
- ►jimmunol.org HTC Kreuwel, JA Biggs, IM Pilip, EG Pamer, … - The Journal of Immunology, 2001 - Am Assoc Immnol Nonobese diabetic (NOD) mice develop spontaneous autoimmune diabetes that
involves participation of both CD4 + and CD8 + T cells. Previous studies have
demonstrated spontaneous reactivity to self-Ags within the CD4 + T cell ... Cited by 40 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org LS Wicker, G Chamberlain, K Hunter, D … - The Journal of Immunology, 2004 - Am Assoc Immnol At least two loci that determine susceptibility to type 1 diabetes in the NOD
mouse have been mapped to chromosome 1, Idd5.1 (insulin-dependent diabetes 5.1)
and Idd5.2. In this study, using a series of novel NOD.B10 congenic ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org [PDF] NJ Hill, PA Lyons, N Armitage, JA Todd, LS … - Diabetes, 2000 - Am Diabetes Assoc A genome scan for B10-derived loci that reduce the fre- quency of diabetes and
insulitis in NOD mice demon- strated a large region (34 cM) of linkage on the
proxi- mal end of chromosome 1. This locus was designated Idd5 and ... Cited by 127 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org K Hunter, D Rainbow, V Plagnol, JA Todd, LB … - The Journal of Immunology, 2007 - Am Assoc Immnol Two loci, Idd5.1 and Idd5.2, that determine susceptibility to type 1 diabetes
(T1D) in the NOD mouse are on chromosome 1. Idd5.1 is likely accounted for by a
synonymous single nucleotide polymorphism in exon 2 of Ctla4: the ... Cited by 10 - Related articles - All 3 versions
PA Lyons, LS Wicker - Genes and Genetics of Autoimmunity, 1999 - books.google.com Theofilopoulos AN (ed): Genes and Genetics of Autoimmunity. Curr Dir Autoimmun.
Basel, Karger, 1999, vol 1, pp 208-225 Localising Quantitative Trait Loci in the
NOD Mouse Model of Type 1 Diabetes Paul A. Lyons'", Linda S. Wicker* " ... Cited by 23 - Related articles - BL Direct - All 4 versions
