- ►diabetesjournals.org DS Zatechka, PF Kador, S Garcia-Castiñeiras … - Diabetes, 2003 - Am Diabetes Assoc Diabetes is known to affect cataract formation by means of osmotic stress
induced by activated aldose reductase in the sorbitol pathway. In addition,
alterations in the bioavailability of numerous extralenticular growth ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►iovs.org G Chandrasekher, HEP Bazan - Investigative ophthalmology & visual science, 2000 - ARVO METHODS. Concentric fiber cell layers from single bovine lens were prepared by
dissolution in buffer. PI-3K activity in capsule-epithelium and fiber cell
layers was determined after immunoprecipitation with antibodies against ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►iovs.org G Chandrasekher, D Sailaja - Investigative ophthalmology & visual science, 2003 - ARVO RESULTS. The PI-3K inhibitors wortmannin and LY294002 blocked the insulin-,
insulin-like growth factor (IGF)-1-, and fibroblast growth factor
(FGF)-2-promoted cell proliferation in rabbit lens epithelial cells. ... Cited by 10 - Related articles - BL Direct - All 5 versions
[CITATION] Role for 12/15-lipoxygenase in diabetic neuropathy
D Steven Zatechka, MF Lou - Experimental eye research, 2002 - Elsevier The lens possesses comprehensive mitogen-activated signal transduction pathways
(MAPK), which include the mitogen response pathway (Raf-MEK-ERK cascade), the
stress-response pathways (p38 and SAPK/JNK cascades) and also the survival ... Cited by 21 - Related articles - BL Direct - All 6 versions
- ►iovs.org X Gong, X Wang, J Han, I Niesman, Q Huang, … - Investigative ophthalmology & visual science, 2001 - ARVO METHODS. The members of the ERK pathway in the lens were examined by Western
blotting, immunohistochemical staining, and kinase assay. A gain-of-function
approach was used to perturb the ERK pathway in the lenses of transgenic ... Cited by 30 - Related articles - BL Direct - All 6 versions
D Steven Zatechka, MF Lou - Experimental eye research, 2002 - Elsevier The current understanding of the cellular signal transduction system is that
cells initially respond to outside stimuli, such as growth factors or
neurotransmitters, through ligand binding to the respective growth factor ... Cited by 39 - Related articles - BL Direct - All 7 versions
- ►iovs.org J Zhou, AS Menko - Investigative ophthalmology & visual science, 2002 - ARVO METHODS. A whole-lens culture system was developed, in which cortical opacities
formed within 5 days, in embryonic day (E)10 lenses grown in medium containing
10% fetal bovine serum. SFK activity was blocked in the cultured lenses by ... Cited by 15 - Related articles - BL Direct - All 3 versions
G Chandrasekher, D Sailaja - Current Eye Research, 2004 - informahealthcare.com Results. Protein tyrosine phosphorylation in the lens was disrupted before the
onset of cataract. A decrease in tyrosine phosphorylation of lens proteins was
observed within 2–3 days of selenite injection (pre-cataract stage). The ... Cited by 6 - Related articles - BL Direct - All 7 versions
