- ►diabetesjournals.org I Briaud, MK Lingohr, LM Dickson, CE Wrede … - Diabetes, 2003 - Am Diabetes Assoc Glucose can activate the mitogen-activated kinases, Erk-1/2, and the
ribosomal-S6 kinase, p70 S6K , in β-cells, contributing to an increase in
mitogenesis. However, the signaling mechanism by which glucose induces ... Cited by 76 - Related articles - BL Direct - All 4 versions
E Gomez, C Pritchard, TP Herbert - Journal of Biological Chemistry, 2002 - ASBMB Glucagon like peptide-1 (GLP1) is a G s -coupled receptor agonist that exerts
multiple effects on pancreatic -cells, including the stimulation of insulin gene
expression and secretion. In this report, we show that treatment of the ... Cited by 84 - Related articles - BL Direct - All 8 versions
- ►pubget.com [PDF] MK Lingohr, LM Dickson, JF McCuaig, SR … - Diabetes, 2002 - Am Diabetes Assoc Transforming growth factor (TGF)-α- and epidermal growth factor (EGF)-induced
signal transduction was directly compared with that of glucose and insulin-like
growth factor-1 (IGF-1) in INS-1 cells. TGF-α/EGF transiently (<20 min) ... Cited by 85 - Related articles - BL Direct - All 7 versions
MK Lingohr, LM Dickson, CE Wrede, JF … - Molecular and cellular endocrinology, 2003 - Elsevier IRS-2 plays an important role in the control of pancreatic β-cell growth,
however it is unclear if other IRS family members are also involved. Using
recombinant adenoviruses, IRS-1, -2 and -3 expression was varied in the ... Cited by 19 - Related articles - All 5 versions
LM Dickson, MK Lingohr, J McCuaig, SR Hugl … - Journal of Biological Chemistry, 2001 - ASBMB It has been shown that IGF-1-induced pancreatic -cell proliferation is
glucose-dependent; however, the mechanisms responsible for this glucose
dependence are not known. Adenoviral mediated expression of constitutively ... Cited by 83 - Related articles - BL Direct - All 6 versions
- ►jbc.org C Benes, MP Roisin, H Van Tan, C Creuzet, J … - Journal of Biological Chemistry, 1998 - ASBMB MIN6 is one of the few pancreatic cell lines that respond to physiological
concentrations of glucose by secreting insulin, and little is known about the
triggered molecular mechanisms. We report below that the response to ... Cited by 66 - Related articles - BL Direct - All 5 versions
- ►shouxi.net I Briaud, LM Dickson, MK Lingohr, JF … - Journal of Biological Chemistry, 2005 - ASBMB Regulation of insulin receptor substrate (IRS)-2 expression is critical to
β-cell survival, but the mechanisms that control this are complex and
undefined. Here in pancreatic β-cells (INS-1), chronic exposure (>8 h) to ... Cited by 42 - Related articles - All 5 versions
- ►nih.gov [PDF] C Benes, V Poitout, JC Marie, J Martin-Perez, … - Biochemical Journal, 1999 - pubmedcentral.nih.gov Physiological concentrations of glucose that lead to Ca#+ entry and insulin
secretion activate extracellular signal-regulated pro- tein kinases (ERK1 and
ERK2) in the MIN6 pancreatic β-cell line. Here we show that this ... Cited by 43 - Related articles - BL Direct - All 10 versions
- ►diabetesjournals.org ML McDaniel, CA Marshall, KL Pappan, G … - Diabetes, 2002 - Am Diabetes Assoc Mammalian target of rapamycin (mTOR) is a serine and threonine protein kinase
that regulates numerous cellular functions, in particular, the initiation of
protein translation. mTOR-mediated phosphorylation of both the ... Cited by 43 - Related articles - BL Direct - All 4 versions
D Arnette, TB Gibson, MC Lawrence, B … - Journal of Biological Chemistry, 2003 - ASBMB We showed previously that ERK1/2 were activated by glucose and amino acids in
pancreatic cells. Here we examine and compare signaling events that are
necessary for ERK1/2 activation by glucose and other stimuli in cells. We ... Cited by 45 - Related articles - BL Direct - All 5 versions
