- ►diabetesjournals.org K Eitel, H Staiger, J Rieger, H Mischak, H … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance as well as pancreatic ß-cell failure can be induced by
elevated free fatty acid (FFA) levels. We studied the mechanisms of FFA-induced
apoptosis in rat and human ß-cells. Chronic treatment with high ... Cited by 60 - Related articles - BL Direct - All 4 versions
K Eitel, H Staiger, MD Brendel, H Brandhorst, … - Medizinische Klinik, 2003 - Springer B ei der Entstehung des Diabetes mellitus Typ 2 spielt die -Zell- Dysfunktion
zusammen mit der peri- pheren Insulinresistenz die pathogene- tisch wichtigste
Rolle [1, 2]. Initial führt die periphere Insulinresistenz zu einer -Zell- ... Related articles
- ►diabetesjournals.org L Carpenter, D Cordery, TJ Biden - Diabetes, 2002 - Am Diabetes Assoc Exposure of pancreatic ß-cells to cytokines, such as interleukin-1ß (IL-1ß),
is thought to contribute to the ß-cell apoptosis that underlies the onset of
type 1 diabetes. One important event triggered by IL-1ß is induction of ... Cited by 40 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org [PDF] HJ Welters, SA Smith, M Tadayyon, JH … - Journal of molecular endocrinology, 2004 - Soc Endocrinology Institute of Biomedical and Clinical Science, Peninsula Medical School,
Plymouth, Devon, PL6 8BX, UK 1 GlaxoSmithKline Pharmaceuticals, Harlow, Essex,
UK 2 School of Medicine, Keele University, Staffs, ST5 5BG, UK Cited by 12 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org [PDF] CE Wrede, LM Dickson, MK Lingohr, I Briaud … - Journal of molecular endocrinology, 2003 - Soc Endocrinology It is possible that activation of protein kinase C (PKC) isoforms by free fatty
acids (FFA) plays a role in the failure of pancreatic β-cell mass expansion to
compensate for peripheral insulin resistance in the pathogenesis of type-2 ... Cited by 25 - Related articles - BL Direct - All 4 versions
KL Knutson, M Hoenig - Journal of cellular biochemistry, 1996 - interscience.wiley.com We have previously identified expression of multiple protein kinase C (PKC)
isoforms in insulinoma-derived beta-cells and whole islets. Both PKC and PKC
appear to be the more abundantly expressed isoforms. In this report we ... Cited by 8 - Related articles - BL Direct - All 4 versions
- ►fasebj.org [PDF] M Artwohl, M Roden, W Waldhausl, A … - The FASEB Journal, 2003 - FASEB Page 1. The FASEB Journal express article 10.1096/fj.03-0301fje. Published online
November 3, 2003. Free fatty acids trigger apoptosis and inhibit cell cycle ... Cited by 84 - Related articles - BL Direct - All 5 versions
- ►nih.gov H Zhang, M Nagasawa, S Yamada, H Mogami, … - The Journal of Physiology, 2004 - Physiological Soc The present study was conducted to evaluate the role of conventional protein
kinase C (PKC) in calcium-evoked insulin secretion. In rat β cells transfected
with green fluorescent protein-tagged PKC-α (PKC-α–EGFP), a ... Cited by 13 - Related articles - All 7 versions
R Okuyama, T Fujiwara, J Ohsumi - FEBS letters, 2003 - Elsevier Prolonged exposure to free fatty acids induces β-cell cytotoxicity. We
investigated whether this fatty-acid-induced cytotoxicity is affected by high
glucose levels. In clonal β-cell HIT-T15, palmitate-induced cytotoxicity ... Cited by 14 - Related articles - All 5 versions
K Eitel, H Staiger, MD Brendel, D Brandhorst, … - Biochemical and Biophysical Research …, 2002 - Elsevier It is believed that free fatty acids contribute to the pathogenesis of type 2
diabetes in humans. We have recently shown that lipoapoptosis of human β-cells
is specifically induced by saturated fatty acids while unsaturated had no ... Cited by 42 - Related articles - All 6 versions
