K Yamamoto, H Hashimoto, S Tomimoto, N Shintani, J … - Diabetes, 2003 - Am Diabetes Assoc Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the vasoactive intestinal
peptide/secretin/glucagon family, stimulates insulin secretion from islets in a glucose-dependent
manner at femtomolar concentrations. To assess PACAP's pancreatic function in vivo, we ... Cited by 37 - Related articles - BL Direct - All 4 versions
T Yada, M Sakurada, K Filipsson, M Kikuchi, B … - Annals of the New York …, 2000 - ncbi.nlm.nih.gov PACAP is an islet peptide that serves as an endogenous amplifier of glucose induced insulin
secretion. Furthermore, we has recently found that PACAP also potentiates insulin stimulated
glucose uptake in adipocytes. Therefore, an antidiabetic action of PACAP is possible. In ... Cited by 28 - Related articles - BL Direct - All 3 versions
- ►aspetjournals.org S Tomimoto, H Hashimoto, N Shintani, K Yamamoto, … - Journal of Pharmacology …, 2004 - ASPET Pituitary adenylate cyclase-activating polypeptide (PACAP) is an intraislet neuropeptide and
shares insulinotropic and insulin-sensitizing properties with glucagon-like peptide-1
(GLP-1); however, the pathophysiological significance of PACAP in diabetes remains ... Cited by 13 - Related articles - BL Direct - All 4 versions
GM Portela-Gomes, A Lukinius, O Ljungberg, S … - Regulatory …, 2003 - 万方数据资源系统 Pituitary adenylate cyclase-activating polypeptide (PACAP) is an islet neuropeptide with potent
insulinotropic action. The current study investigates PACAP expression in normal human and
rat pancreatic islets, and whether it is altered in diabetic state. To that end, PACAP ... Cited by 14 - Related articles - All 4 versions
N Shintani, S Tomimoto, H Hashimoto, C Kawaguchi, A … - Life Sciences, 2003 - Elsevier Pituitary adenylate cyclase-activating polypeptide (PACAP) is a pleiotropic neuropeptide implicated
in a broad variety of physiological processes. To assess PACAP's function in vivo, we recently
generated PACAP knockout mice (PACAP −/− ) and transgenic mice overexpressing ... Cited by 19 - Related articles - All 4 versions
K Filipsson, M Kvist-Reimer, B Ahrén - Diabetes, 2001 - Am Diabetes Assoc The neuropeptide pituitary adenylate cyclase–activating polypeptide (PACAP) is ubiquitously
distributed in both the central and peripheral nervous systems and exerts a variety of effects.
PACAP is a neuropeptide in pancreatic islets, where it has been suggested as a ... Cited by 47 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] T Yada, M Sakurada, H Ishihara, M … - The Journal of …, 1997 - pubmedcentral.nih.gov 1. We examined whether pituitary adenylate cyclase-activating polypeptide with 38 or 27 residues
(PACAP-38 or PACAP-27) serves as an intra-islet regulator of glucose-induced insulin secretion
in rats. PACAP antiserum specific for PACAP-38 and PACAP-27 was used to neutralize ... Cited by 63 - Related articles - BL Direct - All 12 versions
KA Klinteberg, S Karlsson, B Ahren - Endocrinology, 1996 - Endocrine Soc Page 1. 0013.7227196/$03.00/O Endocrmology Copyright 0 1996 by The Endocrine Society
Vol. 137, No. 7 Printed m USA Signaling Mechanisms Underlying the Insulinotropic Effect of
Pituitary Adenylate Cyclase-Activating Polypeptide in HIT-T15 Cells ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►endojournals.org F Jamen, R Puech, J Bockaert, P Brabet, G Bertrand - Endocrinology, 2002 - Endocrine Soc Pituitary adenylate cyclase-activating polypeptide (PACAP) is a potentiator of glucose-induced
insulin secretion. PACAP binds to a PACAP-specific receptor (PAC1) and to VPAC receptors
(VPAC1 and VPAC2), which share high affinity for vasoactive intestinal polypeptide (VIP). ... Cited by 21 - Related articles - BL Direct - All 3 versions
M Nakata, S Shioda, Y Oka, I Maruyama, T Yada - Peptides, 1999 - 万方数据资源系统 Pituitary adenylate cyclase-activating polypeptide (PACAP) is localized in pancreatic nerve fibers
and islets and potently augments glucose-induced insulin secretion. The present study explored
a possible extra-pancreatic action of PACAP. The specific PACAP receptor (PAC1 ... Cited by 23 - Related articles - All 3 versions
