K Cejvan, DH Coy, S Efendic - Diabetes, 2003 - Am Diabetes Assoc Exogenously administered somatostatin (SST) inhibits secretion of insulin and
glucagon. Furthermore, it is hypothesized that islet SST regulates glucagon
secretion by a local action. A number of studies utilizing SST antibodies ... Cited by 48 - Related articles - BL Direct - All 4 versions
- ►cell.com E Xu, M Kumar, Y Zhang, W Ju, T Obata, N … - Cell Metabolism, 2006 - Elsevier Excessive secretion of glucagon is a major contributor to the development of
diabetic hyperglycemia. Secretion of glucagon is regulated by various nutrients,
with glucose being a primary determinant of the rate of α cell glucagon ... Cited by 30 - Related articles - All 9 versions
- ►endojournals.org HL Olsen, S Theander, K Bokvist, K Buschard … - Endocrinology, 2005 - Endocrine Soc In isolated rat pancreatic -cells, glucose, arginine, and the sulfonylurea
tolbutamide stimulated glucagon release. The effect of glucose was abolished by
the K ATP -channel opener diazoxide as well as by mannoheptulose and azide, ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org J Gromada, X Ma, M Høy, K Bokvist, A … - Diabetes, 2004 - Am Diabetes Assoc Patch-clamp recordings and glucagon release measurements were combined to
determine the role of plasma membrane ATP-sensitive K + channels (K ATP
channels) in the control of glucagon secretion from mouse pancreatic ... Cited by 59 - Related articles - BL Direct - All 5 versions
A Wendt, B Birnir, K Buschard, J Gromada, A … - Diabetes, 2004 - Am Diabetes Assoc Outside the CNS, GABA and GAD, the enzyme catalyzing the formation of the
neurotransmitter, are present at high levels in the pancreatic β-cells (2,3).
GAD65 is the most abundant, if not the only, isoform of GAD in human islets ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org MA Ravier, GA Rutter - Diabetes, 2005 - Am Diabetes Assoc The mechanisms by which hypoglycemia stimulates glucagon release are still
poorly understood. In particular, the relative importance of direct metabolic
coupling versus paracrine regulation by β-cell secretory products is ... Cited by 65 - Related articles - All 5 versions
- ►physoc.org SO Gopel, T Kanno, S Barg, XG Weng, J … - The Journal of Physiology, 2000 - Physiological Soc The perforated patch whole-cell configuration of the patch-clamp technique was
applied to superficial glucagon-secreting α-cells in intact mouse pancreatic
islets. ... The T-type Ca 2+ , Na + and A-currents were subject to ... Cited by 98 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] CJ Greenbaum, PJ Havel, GJ Taborsky Jr, LJ … - Journal of Clinical Investigation, 1991 - pubmedcentral.nih.gov Inhibition of pancreatic glucagon secretion during hyperglyce- mia could be
mediated by (a) glucose, (b) insulin, (c) somato- statin, or (d) glucose in
conjunction with insulin. To determine the role of these factors in the ... Cited by 40 - Related articles - All 9 versions
- ►jhc.org E Ludvigsen, R Olsson, M Stridsberg, ET … - Journal of Histochemistry and Cytochemistry, 2004 - Histochemical Soc SOMATOSTATIN is a polypeptide hormone that is widely distributed in neural and
endocrine tissue. It exists in two biologically active forms, somatostatin-14
and the N-terminal extended version, somatostatin-28, which is produced by ... Cited by 25 - Related articles - BL Direct - All 4 versions
I Franklin, J Gromada, A Gjinovci, S … - Diabetes, 2005 - Am Diabetes Assoc Glucagon, secreted from islet α-cells, mobilizes liver glucose. During
hyperglycemia, glucagon secretion is inhibited by paracrine factors from other
islet cells, but in type 1 and type 2 diabetic patients, this suppression ... Cited by 74 - Related articles - All 4 versions
