- ►diabetesjournals.org Y Xu, L Lu, C Greyson, J Lee, M Gen, K Kinugawa, CS … - Diabetes, 2003 - Am Diabetes Assoc Thiazolidinediones exert electrophysiologic effects in noncardiac cells in vitro, but to date there
have been no reports of effects on cardiac rhythm. We previously demonstrated that chronic pretreatment
with a thiazolidinedione peroxisome proliferator–activated receptor (PPAR)-γ activator, ... Cited by 21 - Related articles - BL Direct - All 15 versions
- ►physiology.org Y Xu, M Gen, L Lu, J Fox, SO Weiss, RD … - American Journal of …, 2005 - Am Physiological Soc Peroxisome proliferator-activated receptor (PPAR)- modulates substrate metabolism and inflammatory
responses. In experimental rats subjected to myocardial ischemia-reperfusion (I/R), thiazolidinedione
PPAR- activators reduce infarct size and preserve left ventricular function. Troglitazone is ... Cited by 29 - Related articles - All 4 versions
- ►cardiovascres.org CA Lygate, K Hulbert, M Monfared, MA Cole, K … - Cardiovascular …, 2003 - cardiovascres.org Peroxisome proliferator-activated receptor (PPAR ) activators, or thiazolidinediones, are used
as insulin sensitizers in the treatment of diabetes. They also have a range of properties that may
be beneficial in heart failure. For example, pre-treatment with the PPAR activator ... Cited by 59 - Related articles - All 8 versions
- ►physiology.org TM Lee, TF Chou - American Journal of Physiology- Heart and …, 2003 - Am Physiological Soc Troglitazone, an antidiabetic thiazolidinedione, has been shown to have a scavenging effect
on reactive oxygen species, which can modulate expression of connexin43. The study purpose
was to evaluate whether troglitazone provides cardioprotection and to assess whether the ... Cited by 17 - Related articles - BL Direct - All 3 versions
Y Naito, T Yoshikawa - Drugs of Today, 2004 - journals.prous.com Synthetic peroxisome proliferator-activated receptor γ (PPAR-γ) ligands shown to induce adipocyte
differentiation and increase insulin sensitivity, thiazolidinediones have recently been implicated
as regulators of cellular inflammatory and ischemic responses. Thiazolidinediones inhibit ... Cited by 10 - Related articles - All 4 versions
- ►ahajournals.org P Zhu, L Lu, Y Xu, GG Schwartz - Circulation, 2000 - Am Heart Assoc Methods and Results—Juvenile pigs (n=6) were treated with troglitazone (75 mg · kg -1 · d -1
PO) for 8 weeks. Untreated pigs (n=8) served as controls. Under anesthetized, open-chest
conditions, pigs underwent 90 minutes of moderate regional LV ischemia and 90 minutes ... Cited by 79 - Related articles - BL Direct - All 5 versions
S Cuzzocrea - Vascular pharmacology, 2004 - Elsevier Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone receptor
superfamily of ligand-activated transcription factors that are related to retinoid, steroid and thyroid
hormone receptors. The PPAR subfamily comprises of three members, PPAR-α, PPAR-β ... Cited by 25 - Related articles - All 3 versions
[CITATION] H. et al. 2001.. Reduction in stroke with gemfibrozil in men with coronary heart …
Y Naito, T Takagi, K Uchiyama, O Handa, N … - Redox Report, 2002 - ingentaconnect.com Intestinal ischemia-reperfusion (IR) injury is a serious condition resulting from acute mesenteric
ischemia, small bowel transplantation, abdominal aortic aneurysm, severe burns and
hemorrhagic, traumatic or septic shock. 1,2 Recent reports have demonstrated that neu- ... Cited by 38 - Related articles - BL Direct - All 3 versions
