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Scholar Results 1 - 10 of about 101 related to Shanmugam: High glucose-induced expression of proinflammatory cytokine and chemokine genes.... (0.12 sec) 

High glucose-induced expression of proinflammatory cytokine and chemokine genes in …

- diabetesjournals.org
N Shanmugam, MA Reddy, M Guha, R … - Diabetes, 2003 - Am Diabetes Assoc
Monocyte activation and adhesion to the endothelium play important roles in
inflammatory and cardiovascular diseases. These processes are further aggravated
by hyperglycemia, leading to cardiovascular complications in diabetes. We ...
Cited by 122 - Related articles - BL Direct - All 4 versions

High glucose accelerates MCP-1 production via p38 MAPK in vascular endothelial cells


H Takaishi, T Taniguchi, A Takahashi, Y … - Biochemical and Biophysical Research …, 2003 - Elsevier
In diabetes mellitus (DM), hyperglycemia causes cardiovascular lesions through
endothelial dysfunction. Monocyte chemoattractant protein-1 (MCP-1) is
implicated in the pathogenesis of cardiovascular lesions. By using human ...
Cited by 52 - Related articles - BL Direct - All 4 versions

Molecular mechanisms of tumor necrosis factor alpha gene expression in monocytic cells …


M Guha, W Bai, JL Nadler, R Natarajan - Journal of Biological Chemistry, 2000 - ASBMB
Increased oxidative stress has been reported in vivo in the diabetic state via
the production of reactive oxygen species (ROS). Such stress is bound to play a
key role on activation of circulating monocytes, leading to the accelerated ...
Cited by 160 - Related articles - BL Direct - All 5 versions

Regulation of cyclooxygenase-2 expression in monocytes by ligation of the receptor for …


N Shanmugam, YS Kim, L Lanting, R … - Journal of Biological Chemistry, 2003 - ASBMB
Cyclooxygenase-2 (COX-2) enzyme and its inflammatory products such as
prostaglandin E 2 (PGE 2 ) have been implicated in the pathogenesis of several
inflammatory diseases. However their role in diabetic vascular disease is ...
Cited by 80 - Related articles - BL Direct - All 4 versions

Acute hyperglycemia causes intracellular formation of CML and activation of ras, p42/44 …


S Schiekofer, M Andrassy, J Chen, G Rudofsky, … - Diabetes, 2003 - Am Diabetes Assoc
Twenty-three nondiabetic volunteers were divided into three groups. In group A
(n = 9), the glucose infusion was adjusted to maintain blood glucose at 5 mmol/l
(euglycemic clamp). In group B (n = 9), the glucose infusion was adjusted ...
Cited by 83 - Related articles - BL Direct - All 4 versions

Monocyte and neutrophil adhesion molecule expression during acute hyperglycemia and after …

- ahajournals.org
MJ Sampson, IR Davies, JC Brown, K Ivory, … - Arteriosclerosis, thrombosis, and vascular biology, 2002 - Am Heart Assoc
Methods and Results— Twenty-three type 2 diabetes patients and 13 control
patients underwent two oral glucose tolerance tests 14 days apart and took
placebo or 800 IU daily of oral alpha tocopherol between tests. Monocyte ...
Cited by 56 - Related articles - BL Direct - All 8 versions

Molecular mechanisms of high glucose-induced cyclooxygenase-2 expression in monocytes

- diabetesjournals.org
N Shanmugam, G Gonzalo, T Irene, R … - Diabetes, 2004 - Am Diabetes Assoc
The cyclooxygenase (COX)-2 enzyme has been implicated in the pathogenesis of
several inflammatory diseases. However, its role in diabetic vascular disease is
unclear. In this study, we evaluated the hypothesis that diabetic ...
Cited by 35 - Related articles - BL Direct - All 4 versions

Correlation between TNF production, increase of plasma C-reactive protein level and …


NT Foss, EB De Oliveira, CL Silva - International journal of leprosy and other mycobacterial …, 1993 - ncbi.nlm.nih.gov
1: Int J Lepr Other Mycobact Dis. 1993 Jun;61(2):218-26. Correlation between
TNF production, increase of plasma C-reactive protein ...
Cited by 37 - Related articles - BL Direct - All 2 versions

Hyperglycemia induces monocytic release of interleukin-6 via induction of protein kinase C-α …

- diabetesjournals.org
S Devaraj, SK Venugopal, U Singh, I Jialal - Diabetes, 2005 - Am Diabetes Assoc
Diabetes confers an increased propensity to atherosclerosis. Inflammation is
pivotal in atherogenesis, and diabetes is a proinflammatory state. Interleukin
(IL)-6, in addition to inducing the acute-phase response, contributes to ...
Cited by 67 - Related articles - All 5 versions

Serum levels of tumor necrosis factor in insulin-dependent diabetic patients.


MC Foss, NT Foss, GM Paccola, CL Silva - Brazilian journal of medical and biological research= …, 1992 - ncbi.nlm.nih.gov
We determined the serum concentrations of tumor necrosis factor (TNF) in 15
nondiabetic healthy subjects and in 36 insulin-dependent (type I) diabetic
outpatients. The mean (+/- SD) annual fasting plasma glucose, urine glucose ...
Cited by 19 - Related articles - All 3 versions


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