CCC Hung, IS Farooqi, K Ong, J Luan, JM Keogh, M … - Diabetes, 2003 - Am Diabetes Assoc Loss of function mutations in the small heterodimer partner (SHP) gene have been reported to
cause obesity and increased birth weight. We examined the relation between genetic variation
in SHP and birth weight, adiposity, and insulin levels in three independent populations. ... Cited by 28 - Related articles - BL Direct - All 5 versions
S Mitchell, MN Weedon, KR Owen, B Shields, B Wilkins … - Diabetes, 2003 - Am Diabetes Assoc The orphan receptor small heterodimer partner (SHP, NR0B2) modulates the transcription activity
of the MODY1 gene HNF4a. Mutations in SHP were found in 7% of Japanese obese young-onset
type 2 diabetic patients and were associated with moderate obesity and increased birth ... Cited by 24 - Related articles - BL Direct - All 5 versions
SM Echwald, KL Andersen, TIA Sorensen, LH … - Human …, 2004 - interscience.wiley.com Variations of the small heterodimer partner (SHP, NR0B2) gene, an atypical nuclear receptor
that inhibits transactivation by hepatocyte nuclear factor (HNF)-4 , are associated with obesity
among Japanese. The purpose of the study was to evaluate the prevalence of SHP ... Cited by 7 - Related articles - BL Direct - All 5 versions
- ►pnas.org H Nishigori, H Tomura, N Tonooka, M … - Proceedings of the …, 2001 - National Acad Sciences Mutations in several genes encoding transcription factors of the hepatocyte nuclear factor
(HNF) cascade are associated with maturity-onset diabetes of the young (MODY), a monogenic
form of early-onset diabetes mellitus. The ability of the orphan nuclear receptor small ... Cited by 93 - Related articles - BL Direct - All 10 versions
L Wang, J Liu, P Saha, J Huang, L Chan, B … - Cell Metabolism, 2005 - Elsevier Brown adipocytes increase energy production in response to induction of PGC-1α, a dominant
regulator of energy metabolism. We have found that the orphan nuclear receptor SHP
(NR0B2) is a negative regulator of PGC-1α expression in brown adipocytes. Mice lacking ... Cited by 36 - Related articles - All 9 versions
- ►endojournals.org L Wang, J Huang, P Saha, RN Kulkarni, M Hu, … - Molecular …, 2006 - Endocrine Soc The orphan receptor small heterodimer partner (SHP; NROB2) is a transcriptional repressor
that inhibits nuclear receptor signaling in diverse metabolic pathways. Here, we report that SHP
–/– mice exhibited hypoinsulinemia with age, which was associated with increased ... Cited by 23 - Related articles - BL Direct - All 4 versions
- ►jbc.org LJ Borgius, KR Steffensen, JA Gustafsson, E … - Journal of Biological …, 2002 - ASBMB SHP (NROB2) is an atypical orphan nuclear receptor that lacks a DNA-binding domain but contains
a putative ligand-binding domain. Previous studies have revealed that SHP interacts with a variety
of nuclear receptors and inhibits their transcriptional activity, thereby acting as a ... Cited by 66 - Related articles - BL Direct - All 3 versions
L Wang, Y Han, CS Kim, YK Lee, DD Moore - Journal of Biological Chemistry, 2003 - ASBMB The orphan nuclear hormone receptor SHP (gene designation NROB2) is an important component
of a negative regulatory cascade by which high levels of bile acids repress bile acid
biosynthesis. Short term studies in SHP null animals confirm this function and also reveal ... Cited by 37 - Related articles - BL Direct - All 6 versions
K Boulias, N Katrakili, K Bamberg, P Underhill, … - The EMBO …, 2005 - pubmedcentral.nih.gov SHP (small heterodimer partner) is an important component of the feedback regulatory
cascade, which controls the conversion of cholesterol to bile acids. In order to identify the bona
fide molecular targets of SHP, we performed global gene expression profiling combined ... Cited by 43 - Related articles - All 8 versions
- ►endojournals.org JY Kim, K Chu, HJ Kim, HA Seong, KC Park, S … - Molecular …, 2004 - Endocrine Soc Small heterodimer partner (SHP; NR0B2) is an atypical orphan nuclear receptor that lacks a
conventional DNA binding domain (DBD) and represses the transcriptional activity of various
nuclear receptors. In this study, we examined the novel cross talk between SHP and ... Cited by 32 - Related articles - BL Direct - All 4 versions
