CJ Groves, S Wiltshire, D Smedley, KR Owen, TM … - Diabetes, 2003 - Am Diabetes Assoc The gene for insulin-degrading enzyme (IDE) represents a strong positional and biological candidate
for type 2 diabetes susceptibility. IDE maps to chromosome 10q23.3, a region linked to diabetes in
several populations; the rat ... Cited by 40 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Florez, S Wiltshire, CM Agapakis, NP Burtt, PIW de … - Diabetes, 2006 - Am Diabetes Assoc The insulin-degrading enzyme is responsible for the intracellular proteolysis of insulin. Its gene
IDE is located on chromosome 10, in an area with suggestive linkage to type 2 diabetes and related
phenotypes. Due to the impact of ... Cited by 29 - Related articles - BL Direct - All 7 versions
S Karamohamed, S Demissie, J Volcjak, C Liu, N … - Diabetes, 2003 - Am Diabetes Assoc Linkage studies have mapped a susceptibility gene for type 2 diabetes to the long arm of chromosome
10, where we have previously identified a quantitative trait locus that affects fasting blood
glucose within the Framingham Heart ... Cited by 56 - Related articles - BL Direct - All 5 versions
HF Gu, S Efendic, S Nordman, CG Östenson, K Brismar … - Diabetes, 2004 - Am Diabetes Assoc Insulin-degrading enzyme (IDE) plays a principal role in the proteolysis of several peptides in
addition to insulin and is encoded by IDE, which resides in a region of chromosome 10q that is
linked to type 2 diabetes. Two ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org H Fakhrai-Rad, A Nikoshkov, A Kamel, M … - Human Molecular …, 2000 - Oxford Univ Press Genetic analysis of the diabetic GK rat has revealed several diabetes susceptibility loci. Congenic
strains have been established for the major diabetes locus, Niddm1, by transfer of GK alleles onto
the genome of the normoglycemic ... Cited by 86 - Related articles - BL Direct - All 4 versions
RG Bennett, FG Hamel, WC Duckworth - Diabetes, 2003 - Am Diabetes Assoc Amylin (islet amyloid polypeptide) is the chief component of the islet amyloid found in type 2
diabetes, and amylin fibril precursors may be cytotoxic to pancreatic β-cells. Little is known
about the prevention of amylin ... Cited by 37 - Related articles - BL Direct - All 5 versions
P Li, WL Kuo, M Yousef, MR Rosner, WJ Tang - Biochemical and Biophysical …, 2006 - Elsevier Insulin degrading enzyme (IDE), a zinc metalloprotease, can specifically recognize and degrade
insulin, as well as several amyloidogenic peptides such as amyloid β (Aβ) and amylin. The
disruption of IDE function in ... Cited by 13 - Related articles - All 4 versions
JB Meigs, CIM Panhuysen, RH Myers, PWF Wilson, LA … - Diabetes, 2002 - Am Diabetes Assoc Elevated blood glucose levels are the hallmark of type 2 diabetes as well as a powerful risk factor
for development of the disease. We conducted a genome-wide search for diabetes-related genes, using
measures of glycemia as ... Cited by 130 - Related articles - BL Direct - All 5 versions
SH Kwak, YM Cho, MK Moon, JH Kim, BL Park, HS … - Diabetes research and …, 2008 - Elsevier Insulin-degrading enzyme (IDE) is a metalloproteinase which degrades insulin and terminates its
action. Homologous deletion of IDE gene resulted in hyperinsulinemia and glucose intolerance in a
rat model of type 2 diabetes ... Cited by 5 - Related articles - All 14 versions
- ►amjpathol.org W Farris, S Mansourian, MA Leissring, EA Eckman, L … - American Journal of …, 2004 - ASIP The causes of cerebral accumulation of amyloid ß-protein (Aß) in most cases of Alzheimer's disease
(AD) remain unknown. We recently found that homozygous deletion of the insulin-degrading enzyme
(IDE) gene in mice results in an ... Cited by 97 - Related articles - BL Direct - All 7 versions
