- ►diabetesjournals.org S Aiston, B Andersen, L Agius - Diabetes, 2003 - Am Diabetes Assoc High glucose concentration suppresses hepatic glycogenolysis by allosteric inhibition and dephosphorylation
(inactivation) of phosphorylase-a. The latter effect is attributed to a direct effect of glucose on
the conformation of phosphorylase-a. Although glucose-6-phosphate (G6P), like glucose, ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] S Aiston, A Green, M Mukhtar, L Agius - Biochemical Journal, 2004 - pubmedcentral.nih.gov The role of glucose 6-P (glucose 6-phosphate) in regulating the activation state of glycogen synthase
and its translocation is well documented. In the present study, we investigated the effects of glucose
6-P on the activation state and compartmentation of phosphorylase in hepatocytes. ... Cited by 16 - Related articles - BL Direct - All 8 versions
JI Tu, DJ Graves - Biochemical and Biophysical Research …, 1973 - Elsevier Vol. 53, No. 1, 1973 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS INHIBITION
OF THE PHOSPHORYLASE KINASE CATALYZED REACTION BY GLUCOSE6P* JanI Tu and
Donald J. Graves Department of Biochemistry and Biophysics Iowa State University, ... Cited by 18 - Related articles - All 2 versions
- ►jbc.org S Aiston, L Hampson, AM Gomez-Foix, JJ … - Journal of Biological …, 2001 - ASBMB We used metabolic control analysis to determine the flux control coefficient of phosphorylase
on glycogen synthesis in hepatocytes by titration with a specific phosphorylase inhibitor
(CP-91149) or by expression of muscle phosphorylase using recombinant adenovirus. ... Cited by 53 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] J Cadefau, M Bollen, W Stalmans - Biochemical Journal, 1997 - pubmedcentral.nih.gov Non-metabolized glucose derivatives may cause inactivation of phosphorylase but, unlike
glucose, they are unable to elicit activation of glycogen synthase in isolated hepatocytes. We
report here that, after the previous inactivation of phosphorylase by one of these glucose ... Cited by 38 - Related articles - BL Direct - All 12 versions
- ►nih.gov [PDF] T Latsis, B Andersen, L Agius - Biochemical Journal, 2002 - pubmedcentral.nih.gov Two distinct allosteric inhibitors of glycogen phosphorylase, 1,4-dideoxy-1,4-imino--arabinitol
(DAB) and CP-91149 (an indole-2-carboxamide), were investigated for their effects on the phosphorylation
state of the enzyme in hepatocytes in itro. CP-91149 induced inactivation ( ... Cited by 25 - Related articles - BL Direct - All 8 versions
- ►nih.gov [PDF] JM Fernandez-Novell, J Arino, S Vilaro, D … - Biochemical …, 1992 - pubmedcentral.nih.gov Incubation of rat hepatocytes with glucose induces the translocation of glycogen synthasefrom
soluble fractions to fractions which sediment at 10000 g. Incubation of the cells with fructose,
galactose, 2-deoxyglucose or 5-thioglucose, which activate glycogen synthase, also ... Cited by 39 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org LJ Hampson, L Agius - Diabetes, 2005 - Am Diabetes Assoc Glucokinase and phosphorylase both have a high control strength over hepatocyte glycogen
metabolism and are potential therapeutic targets for type 2 diabetes. We tested whether combined
phosphorylase inactivation and glucokinase activation is a more effective strategy for ... Cited by 10 - Related articles - All 5 versions
JJ Guinovart, AM Gomez-Foix, J Seoane, JM … - Biochemical Society …, 1997 - ncbi.nlm.nih.gov 1: Biochem Soc Trans. 1997 Feb;25(1):157-60. Bridging the gap between glucose
phosphorylation and glycogen synthesis in the liver. Guinovart JJ, Gómez-Foix AM,
Seoane J, Fernández-Novell JM, Bellido D, Vilaró S. Department ... Cited by 12 - Related articles - BL Direct - All 2 versions
S Aiston, MP Coghlan, L Agius - European Journal of …, 2003 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 27 - Related articles - BL Direct - All 5 versions
