X Wu, H Motoshima, K Mahadev, TJ Stalker, R Scalia, … - Diabetes, 2003 - Am Diabetes Assoc Adiponectin is an abundant adipocyte-derived plasma protein with anti-atherosclerotic and
insulin-sensitizing properties that suppresses hepatic glucose production and enhances glucose
uptake into skeletal muscle. To characterize the potential effects of adiponectin on ... Cited by 223 - Related articles - BL Direct - All 5 versions
E Tomas, TS Tsao, AK Saha, HE Murrey, … - Proceedings of the …, 2002 - National Acad Sciences The hormone ACRP30, also referred to as adiponectin and adipo Q (1), is exclusively secreted
by differentiated adipocytes (2). It circulates in serum as three distinct oligomers: trimer,
hexamer, and an even higher molecular weight species (3). Early studies suggested that ... Cited by 512 - Related articles - BL Direct - All 10 versions
- ►upenn.edu [PDF] H Motoshima, X Wu, K Mahadev, BJ Goldstein - Biochemical and Biophysical …, 2004 - Elsevier Adiponectin (also known as 30-kDa adipocyte complement-related protein or Acrp30) is an abundant
adipocyte-derived plasma protein with anti-atherosclerotic and insulin-sensitizing properties.
In order to investigate the potential mechanism(s) of the vascular protective effect of ... Cited by 185 - Related articles - All 5 versions
T Yamauchi, J Kamon, Y Minokoshi, Y Ito, H Waki, S … - Nature medicine, 2002 - nature.com Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and
glucose and lipid metabolism. However, the signaling pathways that mediate the metabolic effects
of Ad remain poorly identified. Here we show that phosphorylation and activation of the 5'- ... Cited by 1664 - Related articles - BL Direct - All 7 versions
N Ouchi, H Kobayashi, S Kihara, M Kumada, K Sato … - Journal of Biological …, 2004 - ASBMB Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic
properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro
and in vivo. Adiponectin stimulated the differentiation of human umbilical vein ... Cited by 270 - Related articles - BL Direct - All 4 versions
T Yamauchi, J Kamon, H Waki, Y Imai, N … - Journal of Biological …, 2003 - ASBMB The adipocyte-derived hormone adiponectin has been shown to play important roles in the regulation
of energy homeostasis and insulin sensitivity. In this study, we analyzed globular domain adiponectin
(gAd) transgenic (Tg) mice crossed with leptin-deficient ob/ob or apoE-deficient mice. ... Cited by 578 - Related articles - BL Direct - All 10 versions
M Fasshauer, S Kralisch, M Klier, U Lossner, M … - … and Biophysical Research …, 2003 - Elsevier Recently, it has been shown that adiponectin is an important insulin-sensitizing fat-derived protein
which is downregulated in insulin resistance and obesity, and replenishment of which improves
insulin sensitivity. In contrast, interleukin (IL)-6 appears as an adipocytokine serum ... Cited by 294 - Related articles - BL Direct - All 4 versions
T Yamauchi, J Kamon, Y Ito, A Tsuchida, T Yokomizo, S … - Nature, 2003 - nature.com Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) 1, 2, 3, 4
is a hormone secreted by adipocytes that acts as an antidiabetic 5, 6, 7, 8, 9, 10, 11, 12 and
anti-atherogenic 8, 12, 13 adipokine. Levels of adiponectin in the blood are decreased ... Cited by 1242 - Related articles - BL Direct - All 5 versions
K Ma, A Cabrero, PK Saha, H Kojima, L Li, BHJ … - Journal of Biological …, 2002 - ASBMB Previous reports showed that recombinant fragments of adiponectin (adipo) displayed pharmacological
effects when injected into rodents, but the relevance of these observations to the physiological
function of adipo is unclear. We generated Adipo / mice by gene targeting. Adipo / mice ... Cited by 147 - Related articles - BL Direct - All 5 versions
H Chen, M Montagnani, T Funahashi, I Shimomura, … - Journal of Biological …, 2003 - ASBMB Adiponectin is secreted by adipose cells and mimics many metabolic actions of insulin.
However, mechanisms by which adiponectin acts are poorly understood. The vascular action
of insulin to stimulate endothelial production of nitric oxide (NO), leading to vasodilation ... Cited by 454 - Related articles - BL Direct - All 4 versions
