K Højlund, P Stæhr, BF Hansen, KA Green, DG Hardie, … - Diabetes, 2003 - Am Diabetes Assoc In type 2 diabetes, insulin activation of muscle glycogen synthase (GS) is impaired. This defect
plays a major role for the development of insulin resistance and hyperglycemia. In animal
muscle, insulin activates GS by reducing phosphorylation at both NH 2 - and ... Cited by 59 - Related articles - BL Direct - All 4 versions
M Gaster, K Brusgaard, A Handberg, K Højlund, … - … and Biophysical Research …, 2004 - Elsevier The mechanism responsible for the diminished activation of glycogen synthase (GS) in diabetic
myotubes remains unclear, but may involve increased activity and/or expression of glycogen
synthase kinase-3 (GSK-3). In myotubes established from type 2 diabetic and healthy ... Cited by 7 - Related articles - All 5 versions
M Gaster, I Petersen, K Højlund, P Poulsen, H Beck- … - Diabetes, 2002 - Am Diabetes Assoc The most well-described defect in the pathophysiology of type 2 diabetes is reduced insulin-mediated
glycogen synthesis in skeletal muscles. It is unclear whether this defect is primary or acquired
secondary to dyslipidemia, hyperinsulinemia, or hyperglycemia. We determined the ... Cited by 50 - Related articles - BL Direct - All 4 versions
K Hojlund, H Beck-Nielsen - Current Diabetes Reviews, 2006 - ingentaconnect.com Abstract: Insulin resistance in skeletal muscle is a major hallmark of type 2 diabetes and an early
detectable abnormality in the development of this disease. The cellular mechanisms of insulin
resistance include impaired insulin-mediated muscle glycogen synthesis and increased ... Cited by 7 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org [PDF] AV Skurat, AD Dietrich, PJ Roach - Diabetes, 2000 - Am Diabetes Assoc In skeletal muscle, insulin activates glycogen synthase by reducing phosphorylation at both
NH2- and COOH-ter- minal sites of the enzyme and by elevating the levels of
glucose-6-phosphate, an allosteric activator of glycogen synthase. To study the ... Cited by 31 - Related articles - BL Direct - All 4 versions
M Meyer, K Levin, T Grimmsmann, H Beck-Nielsen, H … - Diabetologia, 2002 - Springer Aims/hypothesis. Alterations in insulin signalling could contribute to insulin resistance in Type
II (non-insulin- dependent) diabetes mellitus. Some of these alterations could be secondary to
the diabetic state, ie. the hyper- glycaemia or increased NEFA concentrations. We sought ... Cited by 34 - Related articles - BL Direct - All 3 versions
- ►endojournals.org SE Nikoulina, TP Ciaraldi, L Carter, S Mudaliar, … - Journal of Clinical …, 2001 - Endocrine Soc Insulin signaling pathways potentially involved in regulation of skeletal muscle glycogen synthase
were compared in differentiated human muscle cell cultures from nondiabetic and type 2 diabetic
patients. Insulin stimulation of glycogen synthase activity as well as phosphorylation of ... Cited by 33 - Related articles - BL Direct - All 4 versions
H Beck-Nielsen, A Vaag, P Poulsen, M Gaster - Best Practice & Research …, 2003 - Elsevier Based on our investigations in first-degree relatives, in twins in general, and in monozygotic
twins discordant for type 2 diabetes, we have studied the inheritance of glucose intolerance,
insulin resistance and insulin secretion in order to evaluate the role of genes versus ... Cited by 35 - Related articles - All 6 versions
K Højlund, JFP Wojtaszewski, J Birk, BF Hansen, H … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Recently we reported the coexistence of postprandial hypoglycaemia
and moderate insulin resis- tance in heterozygous carriers of the Arg1174Gln mutation in the
insulin receptor gene (INSR). Controlled studies of in vivo insulin signalling in humans ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►endojournals.org EA McIntyre, R Halse, SJ Yeaman, M … - Journal of Clinical …, 2004 - Endocrine Soc Impaired insulin action is a characteristic feature of type 2 diabetes. The study aims were to investigate
whether after prolonged culture skeletal muscle cultures from insulin-resistant, type 2 diabetic
patients (taking >100 U insulin/d) displayed impaired insulin signaling effects compared ... Cited by 17 - Related articles - All 4 versions
