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Scholar Results 1 - 10 of about 101 related to Sandhu: Low circulating IGF-II concentrations predict weight gain and obesity in humans. (0.11 sec) 

Low circulating IGF-II concentrations predict weight gain and obesity in humans

- diabetesjournals.org
MS Sandhu, JM Gibson, AH Heald, DB Dunger, NJ … - Diabetes, 2003 - Am Diabetes Assoc
Results from experimental and gene-association studies suggest that IGF-II may influence body
weight regulation and that individuals with low IGF-II levels may be more susceptible to weight
gain and obesity. We therefore assessed the association between circulating ...
Cited by 26 - Related articles - BL Direct - All 11 versions

Positive associations between single nucleotide polymorphisms in the IGF2 gene …

- oxfordjournals.org
TR Gaunt, JA Cooper, GJ Miller, INM Day, … - Human Molecular …, 2001 - Oxford Univ Press
We previously demonstrated an association between the insulin-like growth factor 2 (IGF2) gene
3'-untranslated region (3'-UTR) ApaI polymorphism and body mass index (BMI) in over 2500
middle-aged Caucasoid males. In the same cohort, we have now tested association with ...
Cited by 67 - Related articles - BL Direct - All 6 versions

Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular …

- oxfordjournals.org
S Rodriguez, TR Gaunt, SD O'Dell, X Chen, … - Human Molecular …, 2004 - Oxford Univ Press
The IGF2–INS–TH genomic region has been implicated in various common disorders including
the metabolic syndrome, type 2 diabetes and coronary heart disease (CHD). Here we present
detailed haplotype analysis of 2743 males 51–62 years old in relation to body weight and ...
Cited by 30 - Related articles - BL Direct - All 8 versions

High plasma insulin-like growth factor-II and low lipid content in transgenic mice: …


THM Da Costa, DH Williamson, A Ward, P … - Journal of …, 1994 - Soc Endocrinology
Transgenic mice were made by introducing extra copies of the mouse insulin-like growth
factor-II (IGF-II) gene driven by the bovine keratin 10 promoter (BKVI). The adult plasma IGF-II
levels were elevated at least three times in one line. In this line, there was a lower lipid ...
Cited by 32 - Related articles - BL Direct - All 4 versions

Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of …


D Gu, SD O'Dell, X Chen, GJ Miller, IN Day - Human genetics, 2002 - Springer
Abstract The subtelomeric region of 11p harbours three closely linked genes, TH, INS and
IGF2, that have been associated with obesity, size at birth, type I diabetes, poly- cystic ovary
syndrome, overgrowth in Beckwith-Wiede- mann syndrome and possibly hypertension. ...
Cited by 32 - Related articles - BL Direct - All 5 versions

Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle- …


SD O'Dell, GJ Miller, JA Cooper, PC … - Int J Obes Relat …, 1997 - grande.nal.usda.gov
Record Detail. Return to previous page, Save: Title: Apal polymorphism in
insulin-like growth factor II (IGF2) gene and weight in middle-aged males. Author:
O'Dell, SD : Miller, GJ : Cooper, JA : Hindmarsh, PC : Pringle, PJ : Ford ...
Cited by 61 - Related articles - Cached - BL Direct - All 3 versions

Insulin-like growth factor 2 (IGF2) and IGF-binding protein 1 (IGFBP1) gene …


O Ukkola, G Sun, C Bouchard - Diabetologia, 2001 - Springer
Insulin-like growth factors 1 and 2 (IGF1 and IGF2) are important for regulating growth and metabolism
[1]. In biological fluids, IGFs are normally bound to specific binding proteins, insulin-like growth
factor ... ( IGFBP1 ) gene variants are associated with overfeeding-induced
Cited by 19 - Related articles - BL Direct - All 4 versions

Low insulin-like growth factor-II levels predict weight gain in normal weight subjects …


AH Heald, L Kärvestedt, SG Anderson, J … - The American Journal of …, 2006 - Elsevier
At follow-up, 90 participants (40.2%) gained more than 2.0 kg in body weight. For subjects (body
mass index <26) at baseline, mean IGF-II levels were significantly lower in those who gained
more than 2 kg in weight than in subjects of stable weight, 454 ng/mL (95% confidence ...
Cited by 7 - Related articles - All 2 versions

Replication of IGF2-INS-TH&ast; 5 haplotype effect on obesity in older men and …


S Rodríguez, TR Gaunt, E Dennison, X Chen, HE … - European Journal of …, 2005 - nature.com
Interindividual variation of the IGF2-INS-TH region influences risk of a variety of diseases and
complex traits. Previous studies identified a haplotype (designated IGF2-INS-TH * 5 and tagged
by allele A of IGF2 ApaI, allele 9 of TH01 and class I alleles of INS VNTR) associated with ...
Cited by 11 - Related articles - BL Direct - All 5 versions

Deletion of a nuclease-sensitive region between the Igf2 and H19 genes leads to …

- oxfordjournals.org
BK Jones, J Levorse, SM Tilghman - Human Molecular Genetics, 2001 - Oxford Univ Press
The insulin-like growth factor 2 gene (Igf2) is imprinted in most somatic tissues of the mouse
with the exception of the choroid plexus and leptomeninges of the brain, where it is expressed
from both alleles. The imprinting of Igf2 is dependent upon an imprinting control region ...
Cited by 38 - Related articles - BL Direct - All 4 versions


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