- ►diabetesjournals.org Y Liu, Y Nakagawa, Y Wang, R Li, X Li, T Ohzeki, TC … - Diabetes, 2003 - Am Diabetes Assoc Glucocorticoids have been implicated as pathophysiological mediators of obesity and insulin
resistance and are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This
enzyme regenerates active corticosterone from inactive 11-keto forms. To assess the role ... Cited by 38 - Related articles - BL Direct - All 7 versions
- ►aspetjournals.org DEW Livingstone, BR Walker - Journal of Pharmacology and Experimental …, 2003 - ASPET In liver and adipose tissue, 11 -hydroxysteroid dehydrogenase type 1 (11 -HSD1) regenerates
glucocorticoids from inactive 11-keto metabolites. Pharmacological inhibition or transgenic disruption
of 11 -HSD1 attenuates glucocorticoid action and increases insulin sensitivity. Increased ... Cited by 49 - Related articles - BL Direct - All 3 versions
[CITATION] Subcutaneous adipose 11β-hydroxysteroid dehydrogenase type 1 activity and …
RS Lindsay, A Tataranni, P Permana, DEW Livingstone … - J Clin Endocrinol Metab, 2003 Cited by 19 - Related articles
- ►endojournals.org NM Morton, L Ramage, JR Seckl - Endocrinology, 2004 - Endocrine Soc The enzyme 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1) amplifies intracellular glucocorticoid
action in vivo. 11ß-HSD-1 activity is increased in adipose tissues of obese humans and genetically
obese rodents, providing a mechanistic basis for the similarities between metabolic ... Cited by 45 - Related articles - BL Direct - All 5 versions
- ►endojournals.org D Tiosano, I Eisentein, D Militianu, GP … - Journal of Clinical …, 2003 - Endocrine Soc After extensive suprasellar operations for hypothalamic tumor removal, some patients develop
Cushing-like morbid obesity while they receive replacement doses of glucocorticoids. In this
study, we examined the hypothesis that target tissue conversion of inactive ... Cited by 38 - Related articles - BL Direct - All 5 versions
- ►endojournals.org RC Andrews, O Rooyackers, BR Walker - Journal of Clinical …, 2003 - Endocrine Soc Six diet-controlled nonobese diabetic patients with hemoglobin A 1c less than 8%, and six matched
controls participated in a double-blind, cross-over comparison of carbenoxolone (100 mg every
8 h, orally, for 7 d) and placebo. They were admitted overnight for infusions of insulin (as ... Cited by 117 - Related articles - BL Direct - All 10 versions
- ►endojournals.org DJ Wake, E Rask, DEW Livingstone, S … - Journal of Clinical …, 2003 - Endocrine Soc 11ß-HYDROXYSTEROID DEHYDROGENASE TYPE 1 (11HSD1) is a potential target for pharmacological
inhibition in obesity and the metabolic syndrome. It catalyzes the conversion of inactive cortisone
to active cortisol, thereby amplifying activation of intracellular glucocorticoid receptors ... Cited by 139 - Related articles - All 6 versions
- ►endocrinology-journals.org [PDF] DE Livingstone, CJ Kenyon, BR Walker - Journal of Endocrinology, 2000 - Soc Endocrinology Obesity has been associated with alterations in gluco- corticoid metabolism in both man and
rodents, but the underlying mechanisms remain undefined. We have previously reported
tissue-specific alterations in 11- hydroxysteroid dehydrogenase type 1 (11-HSD1) in ... Cited by 53 - Related articles - BL Direct - All 5 versions
E Caramelli, P Strippoli, T Di Giacomi, C … - Endocrine …, 2001 - informahealthcare.com There is increasing evidence that in human obesity, particularly the abdominal phenotype, the
activity of the hypothalamic-pituitary-adrenal (HPA) axis is disregulated. At least two distinct alterations
have been reported: one is characterized by several neuroendocrine abnormalities and ... Cited by 17 - Related articles - BL Direct - All 4 versions
DJ Morris, GW Souness, SA Latif, MP Hardy, AS Brem - Metabolism, 2004 - Elsevier Glucocorticoids are metabolized by isoforms of the enzyme 11β-hydroxysteroid dehydrogenase
(11β-HSD). There is some controversy concerning the bile acid, chenodeoxycholic acid
(CDCA), as a potential endogenously produced inhibitor of 11β-HSD. The present ... Cited by 9 - Related articles - All 10 versions
