- ►diabetesjournals.org VV Tran, G Chen, CB Newgard, HE Hohmeier - Diabetes, 2003 - Am Diabetes Assoc We have been investigating the potential utility of engineered cell lines as surrogates for primary
islet cells in treatment of type 1 diabetes. To this end, two strategies that have emerged for
procuring cell lines with ... Cited by 36 - Related articles - BL Direct - All 4 versions
HE Hohmeier, VV Tran, G Chen, R Gasa, CB … - International Journal of …, 2003 - nature.com Inflammation plays an important role in the destruction of pancreatic islet -cells that leads to
type I diabetes. This involves infiltration of T-cells and macrophages into the islets and local
production of inflammatory ... Cited by 24 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org J Allison, H Thomas, D Beck, JL Brady, AM … - International …, 2000 - Jpn Soc Immunol Insulin-dependent diabetes mellitus results when > 90% of the insulin-producing ß cells in the
pancreatic islets are killed as a result of autoimmune attack by T cells. During the progression to
diabetes, islet ß cells die as a ... Cited by 26 - Related articles - BL Direct - All 4 versions
G Chen, HE Hohmeier, CB Newgard - Journal of Biological Chemistry, 2001 - ASBMB Destruction of pancreatic islet -cells in type 1 diabetes appears to result from direct contact with
infiltrating T-cells and macrophages and exposure to inflammatory cytokines such as interferon
(IFN)- , interleukin (IL)-1 , and ... Cited by 23 - Related articles - BL Direct - All 5 versions
I BetaGene - Journal of Biological Chemistry - ASBMB Page 1. M0:08330, revised, 9-30-00 Expression of the Transcription Factor STAT-1 α in Insulinoma Cells
Protects Against Cytotoxic Effects of Multiple Cytokines Guoxun Chen 1 , Hans E. Hohmeier 2,4 , Christopher
B. Newgard 1,3,4 1 Departments of Biochemistry and Internal Medicine & ... Related articles
P Dupraz, C Rinsch, WF Pralong, E Rolland, R … - Gene therapy, 1999 - 万方数据资源系统 Lentivirus-mediated Bcl-2 expression in betaTC-tet cells improves resistance to hypoxia and
cytokine-induced apoptosis while preserving in vitro and in vivo control of insulin secretion. ...
1. 外文期刊 Hypoxia- and ... Cited by 59 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org [PDF] G Chen, HE Hohmeier, R Gasa, VV Tran, CB Newgard - Diabetes, 2000 - Am Diabetes Assoc Engineered insulinoma cell lines may represent an alternative to isolated islets for transplantation
ther- apy of type 1 diabetes. Success of this approach may require development of cell lines that
can withstand cytokine-mediated ... Cited by 47 - Related articles - BL Direct - All 3 versions
D Thomas, H Yang, DJ Boffa, R Ding, VK Sharma, M … - Transplantation, 2002 - ncbi.nlm.nih.gov BACKGROUND: Apoptosis is a well-documented pathway for islet cell death. One potential mechanism is
overexpression of death-promoting Bax compared with antiapoptotic Bcl-2 in islets. METHODS: We
isolated islets from 10 human ... Cited by 38 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org [PDF] A Rabinovitch, W Suarez-Pinzon, K Strynadka, Q Ju, D … - Diabetes, 1999 - Am Diabetes Assoc Apoptosis has been identified as a mechanism of pan- creatic islet -cell death in autoimmune
diabetes. Proinflammatory cytokines are candidate mediators of -cell death in autoimmune diabetes,
and these cytokines can induce ... Cited by 148 - Related articles - BL Direct - All 4 versions
H Iwahashi, T Hanafusa, Y Eguchi, H Nakajima, J … - Diabetologia, 1996 - Springer Summary Cytokines are thought to contribute to the induction of pancreatic beta-cell destruction in
in- sulin-dependent diabetes mellitus. The molecular mechanisms that underlie beta-cell death were
inves- tigated by studying cytokine- ... Cited by 95 - Related articles - BL Direct - All 3 versions
