- ►diabetesjournals.org GR Rayat, ZA Johnson, JN Beilke, GS Korbutt, RV … - Diabetes, 2003 - Am Diabetes Assoc Cellular xenograft rejection involves a pronounced contribution of CD4 T-cells recognizing antigens
in association with recipient MHC class II molecules. However, the requirement for such
“indirect” antigen recognition for acute islet xenograft is not clear, especially as a function ... Cited by 20 - Related articles - BL Direct - All 4 versions
GR Rayat, RG Gill - Current Diabetes Reports, 2003 - Springer Introduction Neovascularized cellular xenografts were once thought to be relatively impervious
to rapid xenograft rejection seen in vascularized grafts. However, numerous studies show that
islet xenografts clearly trigger rapid rejection in vivo. Both innate and antigen-specific ( ... Cited by 8 - Related articles - BL Direct - All 2 versions
BJ Olack, A Jaramillo, ND Benshoff, Z Kaleem … - …, 2002 - interscience.wiley.com We have previously demonstrated that human T cells responding to porcine islets are primarily
CD4+ and recognized porcine major histocompatibility complex class I molecules through the
indirect pathway of antigen presentation. To determine whether this mechanism is ... Cited by 15 - Related articles - BL Direct - All 3 versions
M Koulmanda, A Qipo, RN Smith, H … - …, 2003 - interscience.wiley.com Abstract: In addition to providing a large source of donor tissue, xenogeneic islet transplantation
might avoid recurrent autoimmunity in patients with type 1 diabetes. To examine this possibility
further, xenogeneic pig islets were transplanted into recipient mice in the presence or ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org GR Rayat, RG Gill - Diabetes, 2005 - Am Diabetes Assoc A variety of transient therapies directed against molecules involved in T-cell activation and function
result in long-term islet allograft survival. However, there are relatively few examples of durable
islet xenograft survival using similar short-term approaches, especially regarding highly ... Cited by 17 - Related articles - All 5 versions
- ►wur.nl [PDF] BC Dickson, H Yang, HFJ Savelkoul, G Rowden, N … - Transplantation, 2003 - journals.lww.com 1 Islet Transplantation Laboratory, Department of Pathology, IWK Health Centre and Dalhousie
University, Halifax, Nova Scotia, Canada. Currently a medical student at the University of
Toronto, Ontario, Canada. ... 2 Department of Pathology, Dalhousie University Faculty of ... Cited by 17 - Related articles - BL Direct - All 6 versions
T Kin, GS Korbutt, T Kobayashi, JM Dufour, RV Rajotte - Diabetes, 2005 - Am Diabetes Assoc Neonatal porcine islets (NPIs) are able to grow and to reverse hyperglycemia after transplantation
in immunoincompetent mice. The aim of this study was to demonstrate the feasibility of allogeneic
NPI grafts to achieve normoglycemia in a pancreatectomized diabetic pig. NPIs were ... Cited by 20 - Related articles - All 6 versions
- ►endocrinology-journals.org [PDF] GR Rayat, RV Rajotte, BJ Hering, TM Binette, … - Journal of …, 2003 - Soc Endocrinology The expression of Gal–(1,3)Gal (Gal) on porcine islet cells remains controversial. Several groups
have reported that porcine islet endocrine cells do not express Gal while we have shown in neonatal
porcine islets (NPI) that cells do express this antigen. We hypothesize that endocrine cells ... Cited by 31 - Related articles - BL Direct - All 6 versions
