- ►diabetesjournals.org RN Kulkarni, K Almind, HJ Goren, JN Winnay, … - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is a complex disease in which genetic and environmental factors
interact to produce alterations in insulin action and insulin secretion, leading
to hyperglycemia. To evaluate the influence of genetic background on ... Cited by 64 - Related articles - BL Direct - All 8 versions
K Almind, RN Kulkarni, SM Lannon, CR Kahn - Diabetes, 2003 - Am Diabetes Assoc Mice double heterozygous (DH) for deletion of insulin receptor and insulin
receptor substrate-1 are lean, insulin resistant, and have a phenotype that
strongly depends on the genetic background of the mouse. On the C57BL/6 ... Cited by 30 - Related articles - BL Direct - All 4 versions
[CITATION] Tissue-specific knockouts of the insulin receptor tyrosine kinase
RN Kulkarni, MD Michael, CR Kahn - Genetic Manipulation of Receptor Expression and … Cited by 10 - Related articles
- ►diabetesjournals.org [PDF] Y Kido, N Philippe, AA Schaeffer, D Accili - Diabetes, 2000 - Am Diabetes Assoc Insulin resistance can result from genetic interactions among susceptibility
alleles. To identify genetic loci predisposing to insulin resistance, we used
crosses between different strains of mice with a targeted null allele of ... Cited by 62 - Related articles - BL Direct - All 3 versions
- ►endojournals.org HJ Goren, RN Kulkarni, CR Kahn - Endocrinology, 2004 - Endocrine Soc Transgenic mice phenotypes generally depend on the background strains used in
their creation. To examine the effects of genetic background on insulin
signaling, we analyzed glucose homeostasis in four inbred strains of mice ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►endojournals.org S Kooptiwut, S Zraika, AW Thorburn, ME … - Endocrinology, 2002 - Endocrine Soc REDUCED GLUCOSE-MEDIATED INSULIN secretion is an essential and characteristic
feature of type 2 diabetes (1). The causes of ß-cell dysfunction are not known,
although there is evidence suggesting that ß-cell failure may be preceded ... Cited by 39 - Related articles - BL Direct - All 4 versions
AM Lawrence, RA Prinz, E Paloyan, WA Kokal - Lancet, 1979 - ncbi.nlm.nih.gov 1: Lancet. 1979 Jun 23;1(8130):1354-5. Glucagon and insulin in pancreatic exocrine
secretions. Lawrence AM, Prinz RA, Paloyan E, Kokal WA. ... Cited by 15 - Related articles
R Suzuki, K Tobe, Y Terauchi, K Komeda, N … - Journal of Biological Chemistry, 2003 - ASBMB We previously demonstrated that Irs2 -/- mice develop diabetes due to -cell
growth failure and insulin resistance; however, glucose-induced insulin
secretion was increased in islets isolated from Irs2 -/- mice. Pdx-1, a ... Cited by 24 - Related articles - BL Direct - All 4 versions
Y Kido, J Nakae, ML Hribal, S Xuan, A … - Journal of Biological Chemistry, 2002 - ASBMB Insulin and insulin-like growth factors (IGF) play overlapping and complementary
roles in pancreatic -cell function and peripheral metabolism. In this study, we
have analyzed mice bearing loss-of-function mutations of the insulin/IGF ... Cited by 52 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org T Bock, B Pakkenberg, K Buschard - Diabetes, 2005 - Am Diabetes Assoc Key parameters of the endocrine pancreas, such as islet number, islet mass,
β-cell mass, and α-cell mass, were studied in different strains of inbred mice
to investigate the impact of genetic background on the size and structure ... Cited by 23 - Related articles - All 6 versions
