K Almind, RN Kulkarni, SM Lannon, CR Kahn - Diabetes, 2003 - Am Diabetes Assoc Mice double heterozygous (DH) for deletion of insulin receptor and insulin
receptor substrate-1 are lean, insulin resistant, and have a phenotype that
strongly depends on the genetic background of the mouse. On the C57BL/6 ... Cited by 30 - Related articles - BL Direct - All 4 versions
[CITATION] Tissue-specific knockouts of the insulin receptor tyrosine kinase
RN Kulkarni, MD Michael, CR Kahn - Genetic Manipulation of Receptor Expression and … Cited by 10 - Related articles
- ►diabetesjournals.org RN Kulkarni, K Almind, HJ Goren, JN Winnay, … - Diabetes, 2003 - Am Diabetes Assoc Type 2 diabetes is a complex disease in which genetic and environmental factors
interact to produce alterations in insulin action and insulin secretion, leading
to hyperglycemia. To evaluate the influence of genetic background on ... Cited by 65 - Related articles - BL Direct - All 8 versions
AM Lawrence, RA Prinz, E Paloyan, WA Kokal - Lancet, 1979 - ncbi.nlm.nih.gov 1: Lancet. 1979 Jun 23;1(8130):1354-5. Glucagon and insulin in pancreatic exocrine
secretions. Lawrence AM, Prinz RA, Paloyan E, Kokal WA. ... Cited by 15 - Related articles
- ►diabetesjournals.org [PDF] Y Kido, N Philippe, AA Schaeffer, D Accili - Diabetes, 2000 - Am Diabetes Assoc Insulin resistance can result from genetic interactions among susceptibility
alleles. To identify genetic loci predisposing to insulin resistance, we used
crosses between different strains of mice with a targeted null allele of ... Cited by 62 - Related articles - BL Direct - All 3 versions
[CITATION] Transgenic mice expressing a constitutively active Akt1/PKBα in pancreatic islet β-cells …
T Kayo, H Fujita, J Nozaki… - Comparative medicine, 2000 - ncbi.nlm.nih.gov BACKGROUND AND PURPOSE: Our objective was to map the genes responsible for poor
glucose tolerance in a C57BL/6 (B6) mouse model, which provides a human model of
non-insulin-dependent diabetes mellitus. Insulin secretion was found to be ... Cited by 16 - Related articles - BL Direct
JW Shaw, EO Latimer - American Journal of Physiology, 1926 - Am Physiological Soc Regeneration or extensive new growth of the pancreatic duct has been report,ed
by Fisher (1924b), and regeneration of pancreas tissue (acini and islets) from
the pancreatic duct tissue have been reported by several in- vestigators, ... Cited by 27 - Related articles
J Suto, K Sekikawa - International journal of obesity, 2002 - cat.inist.fr KK and KK-Ay mice serve as animal models of non-insulin-dependent diabetes
mellitus with moderate obesity. Quantitative trait locus(QTL) analysis was
performed to identify gene loci that account for fasting hyperglycemia, ... Cited by 9 - Related articles - BL Direct - All 3 versions
K Eto, T Yamashita, Y Tsubamoto, Y Terauchi, … - Diabetes, 2002 - Am Diabetes Assoc The role of phosphatidylinositol (PI) 3-kinase in the regulation of pancreatic
ß-cell function was investigated. PI 3-kinase activity in p85 regulatory
subunit–deficient (p85 -/- ) islets was decreased to 20% of that in ... Cited by 43 - Related articles - BL Direct - All 5 versions
