N Stefan, P Kovacs, M Stumvoll, RL Hanson, A … - Diabetes, 2003 - Am Diabetes Assoc Insulin receptor substrate (IRS)-2 plays an important role in insulin signaling
and its disruption results in diabetes in mice. In humans, the IRS-2 Gly1057Asp
substitution was associated with lower risk of type 2 diabetes in lean ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org S Mammarella, F Romano, A Di Valerio, B … - Human Molecular Genetics, 2000 - Oxford Univ Press The insulin receptor substrate-2 (IRS-2) is a major insulin signalling molecule.
IRS-2 inactivation in mice induces a form of diabetes characterized by
peripheral insulin resistance and reduced beta cell mass. We tested the ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Fritsche, A Madaus, W Renn, O Tschritter, A … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc Disruption of the insulin receptor substrate-2 was shown to cause type 2
diabetes in mice. This could be largely attributed to abnormal ß-cell
development. In humans, a prevalent polymorphism in insulin receptor ... Cited by 14 - Related articles - BL Direct - All 5 versions
H Wang, J Rissanen, R Miettinen, P … - Diabetes, 2001 - Am Diabetes Assoc We investigated the significance of the variants of the IRS-2 gene in patients
with type 2 diabetes. The entire coding part of the IRS-2 gene was screened by
single-strand conformation polymorphism analysis in 40 Chinese and 40 ... Cited by 21 - Related articles - BL Direct - All 4 versions
D Bernal, K Almind, L Yenush, M Ayoub, Y … - DIABETES-NEW YORK-, 1998 - Am Diabetes Assoc Type 2 diabetes is a complex disease characterized by insulin resistance in
target tissues and a reduced capacity to produce compensatory levels of insulin
in pancreatic -cells (1). Not surpris- ingly, a single molecular defect ... Cited by 67 - Related articles - BL Direct - All 7 versions
- ►endojournals.org R D'Alfonso, MA Marini, L Frittitta, R Sorge, S … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc We investigated the significance of Gly1057Asp and Leu647Val insulin receptor
substrate (IRS)-2 polymorphisms in two Italian cohorts comprising 186
glucose-tolerant subjects and 240 subjects with type 2 diabetes from the ... Cited by 15 - Related articles - BL Direct - All 5 versions
- ►whitelabs.org [PDF] K Almind, SK Frederiksen, D Bernal, T … - Diabetologia, 1999 - Springer The importance of the insulin receptor substrate-2 (IRS-2) has recently been
investigated in mice in which the homozygous deficiency of IRS-2 causes a Type
II (non-insulin-dependent) diabetes-like pheno- type due to both insulin ... Cited by 47 - Related articles - BL Direct - All 5 versions
N Stefan, A Fritsche, F Machicao, O Tschritter … - Diabetologia, 2004 - Springer To the editor: Insulin receptor substrate (IRS)-2 plays an im- portant role in
insulin signalling and its disruption, in mice, re- sults in diabetes [1]. This
could be attributed largely to hepatic insulin resistance and lack of beta ... Cited by 8 - Related articles - BL Direct - All 5 versions
A Siani, R Iacone, O Russo, G Barba, P Russo, … - Obesity, 2001 - nature.com Research Methods and Procedures: Data from 985 working men (The Olivetti Heart
Study) examined in 1994 were used in a cross-sectional design. A complete
anthropometry was performed; body mass index and waist circumference were ... Cited by 12 - Related articles - BL Direct - All 6 versions
YQ Ma, GN Thomas, MC Ng, JA Critchley, CS … - CLINICAL ENDOCRINOLOGY-OXFORD-, 2003 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 12 - Related articles - BL Direct - All 6 versions
