- ►utexas.edu [PDF] S Karamohamed, S Demissie, J Volcjak, C Liu … - Diabetes, 2003 - Am Diabetes Assoc Linkage studies have mapped a susceptibility gene for type 2 diabetes to the
long arm of chromosome 10, where we have previously identified a quantitative
trait locus that affects fasting blood glucose within the Framingham Heart ... Cited by 56 - Related articles - BL Direct - All 5 versions
CJ Groves, S Wiltshire, D Smedley, KR Owen, … - Diabetes, 2003 - Am Diabetes Assoc The gene for insulin-degrading enzyme (IDE) represents a strong positional and
biological candidate for type 2 diabetes susceptibility. IDE maps to chromosome
10q23.3, a region linked to diabetes in several populations; the rat ... Cited by 40 - Related articles - BL Direct - All 4 versions
HF Gu, S Efendic, S Nordman, CG Östenson, K … - Diabetes, 2004 - Am Diabetes Assoc Insulin-degrading enzyme (IDE) plays a principal role in the proteolysis of
several peptides in addition to insulin and is encoded by IDE, which resides in
a region of chromosome 10q that is linked to type 2 diabetes. Two recent ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Florez, S Wiltshire, CM Agapakis, NP Burtt … - Diabetes, 2006 - Am Diabetes Assoc The insulin-degrading enzyme is responsible for the intracellular proteolysis of
insulin. Its gene IDE is located on chromosome 10, in an area with suggestive
linkage to type 2 diabetes and related phenotypes. Due to the impact of ... Cited by 29 - Related articles - BL Direct - All 7 versions
- ►oxfordjournals.org H Fakhrai-Rad, A Nikoshkov, A Kamel, M … - Human Molecular Genetics, 2000 - Oxford Univ Press Genetic analysis of the diabetic GK rat has revealed several diabetes
susceptibility loci. Congenic strains have been established for the major
diabetes locus, Niddm1, by transfer of GK alleles onto the genome of the ... Cited by 86 - Related articles - BL Direct - All 4 versions
- ►amjpathol.org W Farris, S Mansourian, MA Leissring, EA … - American Journal of Pathology, 2004 - ASIP The causes of cerebral accumulation of amyloid ß-protein (Aß) in most cases of
Alzheimer's disease (AD) remain unknown. We recently found that homozygous
deletion of the insulin-degrading enzyme (IDE) gene in mice results in an ... Cited by 97 - Related articles - BL Direct - All 7 versions
JA Prince, L Feuk, HF Gu, B Johansson, M … - Human mutation, 2003 - interscience.wiley.com Linkage studies have identified a large (>60-Mb) region on chromosome 10q that
segregates with Alzheimer Disease (AD). Within the region, the gene for insulin
degrading enzyme (IDE) represents a notable biological candidate given that ... Cited by 65 - Related articles - BL Direct - All 3 versions
R Abraham, A Myers, F Wavrant-DeVrieze, ML … - Human genetics, 2001 - Springer Abstract Insulin-degrading enzyme (IDE; insulysin; EC 3.4.24.56) is a 110-kDa
neutral metallopeptidase that can degrade a number of peptides including
β-amyloid. The gene encoding IDE is located on chromosome 10 close to a ... Cited by 88 - Related articles - BL Direct - All 3 versions
SD Edland, F Wavrant-De Vriese, D Compton, … - Neuroscience letters, 2003 - Elsevier Insulin degrading enzyme (IDE) is a protease that degrades insulin and the
β-amyloid peptide implicated in Alzheimer's disease (AD). We reexamined data on
five previously reported IDE polymorphisms stratifying the analysis by the ... Cited by 47 - Related articles - All 4 versions
W Farris, MA Leissring, ML Hemming, AY … - Biochemistry, 2005 - pubs.acs.org Deletion of insulin-degrading enzyme (IDE) in mice causes accumulation of
cerebral amyloid β-protein (Aβ), hyperinsulinemia, and glucose intolerance.
Together with genetic linkage and allelic association of IDE to Alzheimer's ... Cited by 33 - Related articles - All 5 versions
