SR Smith, F Bai, C Charbonneau, L … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance is a component of type 2 diabetes and often precedes
pancreatic β-cell failure. Contributing factors include obesity and a central
pattern of fat accumulation with a strong genetic component. The adipocyte ... Cited by 113 - Related articles - BL Direct - All 6 versions
- ►endojournals.org A Pizzuti, A Argiolas, R Di Paola, R Baratta, A … - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Resistin is overexpressed in human adipose tissue of obese individuals and is
likely to modulate insulin sensitivity. Resistin is, therefore, a candidate gene
for insulin resistance. We searched for polymorphisms in the resistin gene ... Cited by 63 - Related articles - BL Direct - All 4 versions
YM Cho, BS Youn, SS Chung, KW Kim, HK Lee … - Diabetologia, 2004 - Springer Aims/hypothesis. Resistin is thought to be an impor- tant link between obesity
and insulin resistance. It has been suggested that genetic polymorphism in the
pro- moter of resistin gene is a determinant of resistin mRNA expression ... Cited by 60 - Related articles - BL Direct - All 9 versions
- ►endojournals.org X Ma, JH Warram, V Trischitta, A Doria - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Resistin is a newly identified hormone secreted by adipocytes that inhibits
insulin action on peripheral tissues. The aim of our study was to investigate
whether genetic variability at this locus is associated with the risk of ... Cited by 72 - Related articles - BL Direct - All 4 versions
- ►endojournals.org H Wang, WS Chu, C Hemphill, SC Elbein - Journal of Clinical Endocrinology & Metabolism, 2002 - Endocrine Soc Insulin resistance is strongly associated with obesity, but even among obese
subjects insulin sensitivity varies widely. Recently, a new adipocyte hormone,
resistin, was identified, shown to reduce insulin-mediated glucose uptake, ... Cited by 136 - Related articles - BL Direct - All 4 versions
JC Engert, MC Vohl, SM Williams, P Lepage, JC … - Diabetes, 2002 - Am Diabetes Assoc Diabetes and obesity have long been known to be related. The recently
characterized adipocyte hormone resistin (also called FIZZ3/ADSF) has been
implicated as a molecular link between impaired glucose tolerance (IGT) and ... Cited by 146 - Related articles - BL Direct - All 4 versions
- ►nih.gov H Osawa, K Yamada, H Onuma, A Murakami, M … - The American Journal of Human Genetics, 2004 - Elsevier Insulin resistance is a major cause of type 2 diabetes mellitus (T2DM).
Resistin, an adipocyte-secreted hormone, antagonizes insulin. Transgenic mice
that overexpress the resistin gene (Retn) in adipose tissue are insulin- ... Cited by 88 - Related articles - BL Direct - All 4 versions
H Osawa, H Onuma, A Murakami, M Ochi, T … - Diabetes, 2002 - Am Diabetes Assoc Resistin is a novel polypeptide specifically secreted from adipocytes, and its
serum levels are increased in obese diabetic mice. Resistin antagonizes insulin
and could account for insulin resistance. To determine whether there are ... Cited by 117 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BS Youn, KY Yu, HJ Park, NS Lee, SS Min, … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Resistin is an adipocyte-derived peptide that might play a role in obesity and
insulin resistance. However, its role in humans is largely unclear. Although
many studies have measured the expression of human resistin in tissues, the ... Cited by 133 - Related articles - BL Direct - All 4 versions
H Osawa, H Onuma, M Ochi, A Murakami, J … - Biochemical and Biophysical Research …, 2005 - Elsevier Resistin, secreted from adipocytes, causes insulin resistance in rodents. Its
roles and main source in humans remain unknown. The G/G genotype of resistin
single nucleotide polymorphism, SNP-420, induces type 2 diabetes mellitus ... Cited by 36 - Related articles - All 4 versions
