P She, SC Burgess, M Shiota, P Flakoll, EP Donahue, … - Diabetes, 2003 - Am Diabetes Assoc Liver-specific PEPCK knockout mice, which are viable despite markedly abnormal lipid
metabolism, exhibit mild hyperglycemia in response to fasting. We used isotopic tracer
methods, biochemical measurements, and nuclear magnetic resonance spectroscopy to ... Cited by 47 - Related articles - BL Direct - All 11 versions
- ►nih.gov P She, M Shiota, KD Shelton, R Chalkley, C … - Molecular and cellular …, 2000 - Am Soc Microbiol We used an allelogenic Cre/loxP gene targeting strategy in mice to determine the role of cytosolic
phosphoenolpyruvate carboxykinase (PEPCK) in hepatic energy metabolism. Mice that lack
this enzyme die within 3 days of birth, while mice with at least a 90% global reduction of ... Cited by 80 - Related articles - BL Direct - All 7 versions
- ►jbc.org SC Burgess, N Hausler, M Merritt, FMH Jeffrey, C … - Journal of Biological …, 2004 - ASBMB Liver-specific phosphoenolpyruvate carboxykinase (PEPCK) null mice, when fasted, maintain
normal whole body glucose kinetics but develop dramatic hepatic steatosis. To identify the abnormalities
of hepatic energy generation that lead to steatosis during fasting, we studied metabolic ... Cited by 34 - Related articles - BL Direct - All 9 versions
- ►nih.gov [PDF] S Modaressi, K Brechtel, B Christ, K … - Biochemical …, 1998 - pubmedcentral.nih.gov The mitochodrial (mt) phosphoenolpyruvate carboxykinase 2 (PCK2) gene was isolated by screening
a human genomic library with a rat cytosolic (cy) PCK1 cDNA probe comprising sequences from
exons 2–9 and by PCR amplification of human genomic DNA spanning consecutive ... Cited by 23 - Related articles - BL Direct - All 5 versions
JG Jones, R Naidoo, AD Sherry, FMH Jeffrey, GL … - FEBS letters, 1997 - Elsevier Simple equations that relate glucose and glutamate 13 C-NMR multiplet areas to gluconeogenesis
and pyruvate recycling during metabolism of [1,2,3- 13 C 3 ]propionate are presented. In isolated
rat livers, gluconeogenic flux was 1.2 times TCA cycle flux and about 40% of the ... Cited by 46 - Related articles - All 6 versions
MA Magnuson, P She, M Shiota - Journal of Biological Chemistry, 2003 - ASBMB The regulation of metabolic flux is essential for life, yet our understanding of it remains
incomplete. The ability to determine the role of specific enzymes in regulating metabolic flux
rapidly becomes a nearly overwhelming challenge due to the various interacting ... Cited by 14 - Related articles - BL Direct - All 4 versions
ES Jin, K Uyeda, T Kawaguchi, SC Burgess, CR … - Journal of Biological …, 2003 - ASBMB The generally accepted metabolic concept that fructose 2,6-bisphosphate (Fru-2,6-P 2 ) inhibits
gluconeogenesis by directly inhibiting fructose 1,6-bisphosphatase is based entirely on in vitro
observations. To establish whether gluconeogenesis is indeed inhibited by Fru-2,6-P 2 in ... Cited by 15 - Related articles - BL Direct - All 4 versions
K Chakravarty, H Cassuto, L Reshef, … - Critical reviews in …, 2005 - informahealthcare.com The cytosolic form of PEPCK (PEPCK-C) is generally considered to be the pace-setting enzyme
in hepatic and renal gluconeogenesis (Rognstad, 1979). In this role, alterations in PEPCK-C
mRNA in the liver in response to a wide variety of metabolic perturbations have been ... Cited by 47 - Related articles - All 9 versions
- ►jbc.org Y Sun, S Liu, S Ferguson, LQ Wang, P Klepcyk, JS … - Journal of Biological …, 2002 - ASBMB The ability of insulin to suppress gluconeogenesis in type II diabetes mellitus is impaired;
however, the cellular mechanisms for this insulin resistance remain poorly understood. To address
this question, we generated transgenic (TG) mice overexpressing the ... Cited by 74 - Related articles - BL Direct - All 5 versions
