M Iwaki, M Matsuda, N Maeda, T Funahashi, Y … - Diabetes, 2003 - Am Diabetes Assoc Adiponectin is a fat-derived hormone with antidiabetic and antiatherogenic properties. Hypoadiponectinemia
seen in obesity is associated with insulin-resistant diabetes and atherosclerosis.
Thiazolidinediones, peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists, have ... Cited by 350 - Related articles - BL Direct - All 4 versions
N Maeda, M Takahashi, T Funahashi, S Kihara, H … - Diabetes, 2001 - Am Diabetes Assoc Insulin resistance and its dreaded consequence, type 2 diabetes, are major causes of
atherosclerosis. Adiponectin is an adipose-specific plasma protein that possesses anti-atherogenic
properties, such as the suppression of adhesion molecule expression in vascular ... Cited by 1017 - Related articles - BL Direct - All 4 versions
I Shimomura, T Funahashi, Y … - … -Central Nervous System …, 2003 - ingentaconnect.com ¶ Department of Medicine and Pathophysiology, Graduate School of Frontier Bioscience, Graduate
School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan, ...
Science, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka ... Cited by 4 - Related articles - BL Direct
- ►endojournals.org TP Combs, JA Wagner, J Berger, T Doebber, WJ Wang, … - Endocrinology, 2002 - Endocrine Soc MANY STUDIES HAVE shown that thiazolidinediones (TZDs) produce insulin sensitizing effects
in animal models (1, 2, 3, 4) and in insulin-resistant human subjects (5, 6, 7). It is now clear that
TZDs are high affinity ligands for the nuclear receptor, PPAR , which can transactivate ... Cited by 411 - Related articles - BL Direct - All 4 versions
K Kishida, H Nagaretani, H Kondo, H Kobayashi, S … - … and Biophysical Research …, 2003 - Elsevier Adiponectin, an adipocyte-derived protein, consists of collagen-like fibrous and complement
C1q-like globular domains, and circulates in human plasma in a multimeric form. The protein
exhibits anti-diabetic and anti-atherogenic activities. However, adiponectin plasma ... Cited by 42 - Related articles - All 4 versions
JG Yu, S Javorschi, AL Hevener, YT Kruszynska, RA … - Diabetes, 2002 - Am Diabetes Assoc The insulin-sensitizing effects of thiazolidinediones are thought to be mediated through peroxisome
proliferator-activated receptor-γ, a nuclear receptor that is highly abundant in adipose tissue.
It has been reported that adipocytes secrete a variety of proteins, including tumor necrosis ... Cited by 454 - Related articles - BL Direct - All 5 versions
- ►onlinejacc.org K Ohashi, N Ouchi, S Kihara, T Funahashi, T … - Journal of the American …, 2004 - Elsevier Coronary artery disease is a major cause of mortality in the industrial countries. Adiponectin
gene locus, chromosome 3q27, is the candidate site for CAD. We have reported that adiponectin
has antiatherogenic and antidiabetic properties, and that the plasma levels negatively ... Cited by 115 - Related articles - All 13 versions
H Waki, T Yamauchi, J Kamon, Y Ito, S Uchida, S … - Journal of Biological …, 2003 - ASBMB Adiponectin is an adipocyte-derived hormone, which has been shown to play important roles
in the regulation of glucose and lipid metabolism. Eight mutations in human adiponectin have
been reported, some of which were significantly related to diabetes and ... Cited by 423 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org Y Matsuzawa, T Funahashi, S Kihara, I … - … , and vascular biology, 2004 - Am Heart Assoc In this review article, the crucial roles of adipocytes in the development of so-called metabolic
syndrome and vascular disease are reviewed, focusing on adipocyte-derived bioactive
substances, adipocytokines. Recent progress in adipocyte biology shows that adipocytes ... Cited by 500 - Related articles - BL Direct - All 11 versions
- ►jbc.org JB Seo, HM Moon, MJ Noh, YS Lee, HW Jeong, EJ … - Journal of Biological …, 2004 - ASBMB Adiponectin is exclusively expressed in differentiated adipocytes and plays an important role
in regulating energy homeostasis, including the glucose and lipid metabolism associated with
increased insulin sensitivity. However, the control of adiponectin gene expression in ... Cited by 65 - Related articles - BL Direct - All 5 versions
