ML Bergman, N Duarte, S Campino, M Lundholm, V … - Diabetes, 2003 - Am Diabetes Assoc Type 1 diabetes in the nonobese diabetic (NOD) mouse is a multifactorial and polygenic
disease. The NOD-derived genetic factors that contribute to type 1 diabetes are named Idd
(insulin-dependent diabetes) loci. To date, the biological functions of the majority of the ... Cited by 17 - Related articles - BL Direct - All 4 versions
ML Bergman, C Penha-Goncalves, K Lejon, D … - Diabetologia, 2001 - Springer Non-obese diabetic (NOD) mice spontaneously de- velop autoimmune diabetes, a disease that
closely re- sembles Type I (insulin-dependent) diabetes mellitus in humans [1]. This T-cell-dependent
autoimmune disease is multifactorial and polygenic, with at least 18 separate loci ... Cited by 12 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org UC Rogner, F Lepault, MC Gagnerault, D Vallois, J … - Diabetes, 2006 - Am Diabetes Assoc The genetic locus Idd6 confers susceptibility to the spontaneous development of type 1 diabetes
in the NOD mouse. Our studies on disease resistance of the congenic mouse strain NOD.C3H
6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►oxfordjournals.org MS Hung, P Avner, UC Rogner - Human Molecular Genetics, 2006 - Oxford Univ Press The Idd6 murine type 1 diabetes locus has been shown to control diabetes by regulating the
protective activity of the peripheral immune system, as demonstrated by diabetes transfer assays
using splenocytes. The analysis of three novel subcongenic (NOD.C3H nonobese. C3H) ... Cited by 8 - Related articles - BL Direct - All 6 versions
CH Grimm*, UC Rogner, P Avner - Autoimmunity, 2003 - informahealthcare.com Three type 1 diabetes associated regions on distal mouse chromosome 6 have recently been
defined by the construction and analysis of a series of congenic strains, carrying C3H/HeJ genomic
material on a NOD/Lt genetic background. Whilst NOD/Lt alleles at the most distal locus ... Cited by 6 - Related articles - BL Direct - All 6 versions
C Penha-Gonçalves, K Leijon, L Persson, D Holmberg - Genomics, 1995 - Elsevier MAPPING OF APOPTOSIS RESISTANCE IN MOUSE IDDM 399 screened weekly for glycosuria
from the age of 10 weeks using colori- metrie test strips, and the incidence of diabetes at 30 weeks
of age reaches 70% among females. Dexamethazone treatment. The protocol for ... Cited by 33 - Related articles - BL Direct - All 4 versions
UC Rogner, C Boitard, J Morin, E Melanitou, P Avner - Genomics, 2001 - Elsevier The development of insulin-dependent diabetes mellitus in both human and mouse is dependent
on the interaction between genetic and environmental factors. The analysis of newly created
NOD.C3H congenic strains for spontaneous and cyclophosphamide-induced diabetes ... Cited by 47 - Related articles - BL Direct - All 6 versions
J Morin, C Boitard, D Vallois, P Avner, UC Rogner - Mammalian Genome, 2006 - Springer Abstract In the nonobese diabetes mouse, the murine type 1 diabetes susceptibility locus Idd20
interacts geneti- cally with the diabetes resistance locus Idd19. Both Idds are located on distal
mouse Chromosome 6, and previous studies on NOD.C3H congenic strains have shown ... Cited by 4 - Related articles - BL Direct - All 4 versions
PA Lyons - Current opinion in immunology, 2002 - Elsevier The identification of the genetic variants that confer susceptibility to common autoimmune
diseases, such as type 1 diabetes (T1D) and systemic lupus erythematosus (SLE), will provide
significant insight into their pathogenesis as well as identifying potential new targets for ... Cited by 12 - Related articles - All 5 versions
SE Eckenrode, Q Ruan, P Yang, W Zheng, … - DIABETES-NEW …, 2004 - Am Diabetes Assoc T ype 1 diabetes is a disease manifested when the insulin-producing pancreatic -cells are
de- stroyed by the immune system. Studies using the NOD mouse model, which spontaneously
devel- ops type 1 diabetes, have shown that both B- and T-cells are necessary for the ... Cited by 14 - Related articles - BL Direct - All 4 versions
